Browsing by Author "Ibrahim, Wisam Nabeel"
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3D culture of cancer cells in alginate hydrogel beads as an effective technique for emergency cell storage and transportation in the pandemic era
Alallam, Batoul; May, Kyaw Oo; Ibrahim, Wisam Nabeel; Doolaanea, Abd Almonem ( Wiley , 2021 , Article)Due to the restrictions in access to research lab during the pandemic time and due to existence of challenges in providing proper storage and transportation of cells in developing countries, having an effective and feasible ... -
Cancer Resistance to Immunotherapy: Comprehensive Insights with Future Perspectives
Said, Sawsan Sudqi; Ibrahim, Wisam Nabeel ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Cancer immunotherapy is a type of treatment that harnesses the power of the immune systems of patients to target cancer cells with better precision compared to traditional chemotherapy. Several lines of treatment have been ... -
COVID-19 Vaccine Acceptance among Vulnerable Groups: Syrian Refugees in Jordan
Talafha, Qusai M.; Al-Haidose, Amal; AlSamman, Ala Y.; Abdallah, Saja A.; Istaiteyeh, Rasha; Ibrahim, Wisam Nabeel; Hatmal, Ma’mon M.; Abdallah, Atiyeh M.... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Despite the wide distribution of COVID-19 vaccines, refugees remain last in line for the intake of vaccines. Syrian refugees in Jordan reach up to 700,000 registered and almost up to 700,000 unregistered refugees. This ... -
A Cross-Sectional Study on Bullying and Psychological Disturbances among Malaysian School Children
isa, Muhammad Lokman Md; Mocktar, Nurfatin Aina; Ibrahim, Wisam Nabeel; Nurumal, Mohd Said; Hasan, Muhammad Kamil Che ( Universitas Indonesia , 2021 , Article)Abstract Background: Bullying is a common violence in school and has become a major public health and global concern. Bullying influences mental health and is identified as a leading factor of depression. Therefore, this ... -
Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells
Hassani, Abdelkader; Hussain, Siti Aslina; Al-Qubaisi, Mothanna Sadiq; Belfar, Mohamed Lakhder; Belkhalfa, Hakim; Enezei, Hamid Hammad; Zentou, Hamid; Ibrahim, Wisam Nabeel; Doolaanea, Abd Almonem... more authors ... less authors ( Tech Science Press , 2022 , Article)The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant ... -
Electroencephalographic evidence of gray matter lesions among multiple sclerosis patients: A case-control study.
Salim, Ahmed Abduljawad; Ali, Safaa Hussain; Hussain, Ansam Munadel; Ibrahim, Wisam Nabeel ( Lippincott, Williams & Wilkins , 2021 , Article)This study aimed to investigate evidence of gray matter brain lesions in multiple sclerosis (MS) patients by evaluating the resting state alpha rhythm of brain electrical activity.The study included 50 patients diagnosed ... -
Formulation, Cellular Uptake and Cytotoxicity of Thymoquinone-Loaded PLGA Nanoparticles in Malignant Melanoma Cancer Cells
Ibrahim, Wisam Nabeel; Bin Mohd Rosli, Luqman Muizzuddin; Doolaanea, Abd Almonem ( Dove Medical Press , 2020 , Article)Introduction: Thymoquinone (TQ) is the main active compound extracted from Nigella sativa a traditional herb with wide therapeutic applications and recognizable anticancer properties. This study aimed to formulate and ... -
Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin.
Hassani, Abdelkader; Mahmood, Syed; Enezei, Hamid Hammad; Hussain, Siti Aslina; Hamad, Hamad Ali; Aldoghachi, Ahmed Faris; Hagar, Abdullah; Doolaanea, Abd Almonem; Ibrahim, Wisam Nabeel... more authors ... less authors ( MDPI , 2020 , Article)The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve ... -
Gene Expression Profiling and Protein Analysis Reveal Suppression of the C-Myc Oncogene and Inhibition JAK/STAT and PI3K/AKT/mTOR Signaling by Thymoquinone in Acute Myeloid Leukemia Cells
Almajali, Belal; Johan, Muhammad Farid; Al-Wajeeh, Abdullah Saleh; Wan Taib, Wan Rohani; Ismail, Imilia; Alhawamdeh, Maysa; Al-Tawarah, Nafe M.; Ibrahim, Wisam Nabeel; Al-Rawashde, Futoon Abedrabbu; Al-Jamal, Hamid Ali Nagi... more authors ... less authors ( MDPI , 2022 , Article)Overexpression of c-Myc plays an essential role in leukemogenesis and drug resistance, making c-Myc an attractive target for cancer therapy. However, targeting c-Myc directly is impossible, and c-Myc upstream regulator ... -
Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells
Alshwyeh, Hussah Abdullah; Al-Sheikh, Warqaa Muhammed Shariff; Rasedee, Abdullah; Alnasser, Sulaiman Mohammed; Al-Qubaisi, Mothanna Sadiq; Ibrahim, Wisam Nabeel... more authors ... less authors ( Taylor and Francis Ltd. , 2024 , Article)In this study, we investigated the effects of an ethanolic extract of Mangifera indica L. kernel on the viability and proliferation of human lung cancer cells. We utilized MTT and BrdU cell proliferation assays, morphological ... -
Obesity is associated with depression in Malaysian schoolchildren: A cross-sectional study
Nurumal, Mohd Said; Abidin, Rohulizzat Zainal; Ibrahim, Wisam Nabeel; Md Isa, Muhammad Lokman; Che Hasan, Muhammad Kamil ( Universitas Indonesia , 2020 , Article)Background: Overweight and obesity, which may lead to depression, have become prevalent among children worldwide. Hence, this study aimed to measure obesity and depression among schoolchildren in Kuantan. Methods: This ... -
Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells
Mohamed Qasim, Al-Fahdawi; Al-Doghachi, Faris A.J.; Abdullah, Qasim Khlaif; Hammad, Ruaa Tareq; Rasedee, Abdullah; Ibrahim, Wisam Nabeel; Alshwyeh, Hussah Abdullah; Alosaimi, Areej A; Aldosary, Sahar Khamees; Eid, Eltayeb E.M.; Rosli, Rozita; Taufiq-Yap, Y.H.; Al-Haj, Nagi A.; Al-Qubaisi, Mothanna Sadiq... more authors ... less authors ( Elsevier , 2021 , Article)The aim of this study was to prepare, characterize, and determine the in vitro anticancer effects of platinum-doped magnesia (Pt/MgO) nanoparticles. The chemical compositions, functional groups, and size of nanoparticles ... -
Physicochemical characterization and cancer cell antiproliferative effect of silver-doped magnesia nanoparticles
Mohamed Qasim, Al-Fahdawi; Aldoghachi, Ahmed Faris; Alhassan, Fatah H.; Al-Doghachi, Faris A.J.; Alshwyeh, Hussah Abdullah; Rasedee, Abdullah; Alnasser, Sulaiman Mohammed; Al-Qubaisi, Mothanna Sadiq; Ibrahim, Wisam Nabeel... more authors ... less authors ( Elsevier , 2023 , Article)Silver-doped magnesia nanoparticles (Ag/MgO) were synthesized using the precipitation method and characterized by various techniques such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), thermal ... -
Physicochemical characterization and cancer cell antiproliferative effect of silver-doped magnesia nanoparticles
Mohamed Qasim, Al-Fahdawi; Aldoghachi, Ahmed Faris; Alhassan, Fatah H.; Al-Doghachi, Faris A.J.; Alshwyeh, Hussah Abdullah; Rasedee, Abdullah; Alnasser, Sulaiman Mohammed; Al-Qubaisi, Mothanna Sadiq; Ibrahim, Wisam Nabeel... more authors ... less authors ( Elsevier , 2023 , Article)Silver-doped magnesia nanoparticles (Ag/MgO) were synthesized using the precipitation method and characterized by various techniques such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), thermal ... -
Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles.
Hassani, Abdelkader; Azarian, Mohammad Mahdi Sabaghpour; Ibrahim, Wisam Nabeel; Hussain, Siti Aslina ( Nature Research , 2020 , Article)Gallic acid (GA) is a natural phenolic compound with therapeutic effects that are often challenged by its rapid metabolism and clearance. Therefore, GA was encapsulated using gum arabic into nanoparticles to increase its ... -
Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite
Mothanna Sadiq, Al-Qubaisi; Al-Abboodi, Ashwaq Shakir; Alhassan, Fatah H.; Hussein-Al-Ali, Samer; Flaifel, Moayad Husein; Eid, Eltayeb E.M.; Alshwyeh, Hussah Abdullah; Hussein, Mohd Zobir; Alnasser, Sulaiman Mohammed; Saeed, Mohammed Ibrahim; Rasedee, Abdullah; Ibrahim, Wisam Nabeel... more authors ... less authors ( Elsevier , 2022 , Article)In this study, we formulated Thymoquinone-loaded nanocomposites (TQ-NCs) using high-pressure homogenizer without sodium tripolyphosphate. The TQ-NCs were characterized and their anti-inflammatory determined by the response ... -
The Promise of the Zebrafish Model for Parkinson’s Disease: Today’s Science and Tomorrow’s Treatment
Razali, Khairiah; Othman, Noratikah; Mohd Nasir, Mohd Hamzah; Doolaanea, Abd Almonem; Kumar, Jaya; Ibrahim, Wisam Nabeel; Ibrahim, Norlinah Mohamed; Mohamed, Wael M. Y.... more authors ... less authors ( Frontiers Media , 2021 , Article)The second most prevalent neurodegenerative disorder in the elderly is Parkinson’s disease (PD). Its etiology is unclear and there are no available disease-modifying medicines. Therefore, more evidence is required concerning ... -
Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris
ibrahim, wisam nabeel; Younes, Nadin; Shi, Zumin; Abu-Madi, Marawan Abdelhamid ( Frontiers Media , 2021 , Article)Background: Oxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Although serum uric acid (SUA) has potent antioxidant properties, the findings of many epidemiological and experimental ... -
Thymoquinone Suppresses Cell Proliferation and Enhances Apoptosis of HL60 Leukemia Cells through Re-Expression of JAK/STAT Negative Regulators.
Almajali, Belal; Al-Jamal, Hamid Ali Nagi; Wan Taib, Wan Rohani; Ismail, Imilia; Johan, Muhammad Farid; Doolaanea, Abd Almonem; Ibrahim, Wisam Nabeel; Tajudin, Syed Ahmad... more authors ... less authors ( West Asia Organization for Cancer Prevention (WAOCP) , 2021 , Article)The natural compound, thymoquinone (TQ) has demonstrated potential anticancer properties in inhibiting cell proliferation and promoting apoptosis in myeloid leukemia cells, breast cancer cells, and others. However, the ... -
Thymoquinone, as a Novel Therapeutic Candidate of Cancers
Almajali, Belal; Nagi, Hamid Ali; Taib, Wan Rohani Wan; Ismail, Imilia Ismail; Johan, Muhammad Farid; Doolaanea, Abd Almonem; Ibrahim, Wisam Nabeel... more authors ... less authors ( MDPI , 2021 , Article)To date, natural products are widely used as pharmaceutical agents for many human diseases and cancers. One of the most popular natural products that have been studied for anticancer properties is thymoquinone (TQ). As ...