Browsing by Author "Cox, James J."

Now showing items 1-4 of 4

    • Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions [version 1; referees: 2 approved] 

      BangaBangash M.A.; Alles, Sascha R. A.; Santana-Varela, Sonia; Millet, Queensta; Sikandar, Shafaq; ... more authors ( F1000 Research Ltd , 2018 , Article)
      Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal ...

    • Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity 

      Habib, Abdella M.; Okorokov, Andrei L.; Hill, Beta Matthew Nicholas; Bras, Jose T.; Lee, Man-Cheung; ... more authors ( Elsevier , 2019 , Article)
      The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally ...

    • Molecular basis of FAAH-OUT-associated human pain insensitivity. 

      Mikaeili, Hajar; Habib, Abdella M; Yeung, Charlix Wai-Lok; Santana-Varela, Sonia; Luiz, Ana P; ... more authors ( Oxford University Press , 2023 , Article)
      Chronic pain affects millions of people worldwide and new treatments are needed urgently. One way to identify novel analgesic strategies is to understand the biological dysfunctions that lead to human inherited pain ...

    • Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function 

      Jami, Sina; Deuis, Jennifer R.; Klasfauseweh, Tabea; Cheng, Xiaoyang; Kurdyukov, Sergey; ... more authors ( Nature Research , 2023 , Article)
      Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the ...