Browsing by Author "Shenoy, Sudha K."
Now showing items 1-3 of 3
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Detection of β-Arrestin-Mediated G Protein-Coupled Receptor Ubiquitination Using BRET.
Nagi, Karim; Shenoy, Sudha K ( Humana Press, New York, NY , 2019 , Book chapter)Ubiquitination of G protein-coupled receptors (GPCRs) is an important dynamic posttranslational modification that has been linked to the intracellular trafficking of internalized GPCRs to lysosomes. Ubiquitination of GPCRs ... -
Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs
Toth, Krisztian; Nagi, Karim; Slosky, Lauren M.; Rochelle, Lauren; Ray, Caroline; Kaur, Suneet; Shenoy, Sudha K.; Caron, Marc G.; Barak, Larry S.... more authors ... less authors ( American Chemical Society , 2019 , Article)G-protein-coupled receptors (GPCRs) can bias signaling through distinct biochemical pathways that originate from G-protein/receptor and β-arrestin/receptor complexes. Receptor conformations supporting β-arrestin engagement ... -
In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes
Karim, Nagi; Kaur, Suneet; Bai, Yushi; Shenoy, Sudha K. ( Elsevier , 2020 , Article)Small ubiquitin like modifier (SUMO) conjugation or SUMOylation of βarrestin2 promotes its association with the clathrin adaptor protein AP2 and facilitates rapid β2 adrenergic receptor (β2AR) internalization. However, ...