Browsing by Author "Parray, Aijaz"
Now showing items 1-16 of 16
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Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome.
Mir, Fayaz Ahmad; Mall, Raghvendra; Iskandarani, Ahmad; Ullah, Ehsan; Samra, Tareq A; Cyprian, Farhan; Parray, Aijaz; Alkasem, Meis; Abdalhakam, Ibrahem; Farooq, Faisal; Abou-Samra, Abdul-Badi... more authors ... less authors ( Frontiers , 2022 , Article)Obesity-associated dysglycemia is associated with metabolic disorders. MicroRNAs (miRNAs) are known regulators of metabolic homeostasis. We aimed to assess the relationship of circulating miRNAs with clinical features in ... -
Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients
Akbar, Shayista; Raza, Afsheen; Mohsin, Reyad; Kanbour, Aladdin; Qadri, Shahnaz; Parray, Aijaz; Zar Gul, Abdul Rehman; Philip, Anite; Vijayakumar, Suma; Merhi, Maysaloun; Hydrose, Shereena; Inchakalody, Varghese Philipose; Al-Abdulla, Rajaa; Abualainin, Wafa; Sirriya, Shaza Abu; Al-Bozom, Issam; Uddin, Shahab; Khan, Omar Muhammad; Mohamed Ibrahim, Mohamed Izham; Al Homsi, Ussama; Dermime, Said... more authors ... less authors ( Frontiers Media S.A. , 2023 , Article)Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have significantly changed the treatment outcomes of NSCLC patients with better overall survival. However, 15-40% of the patients still ... -
Circulating microparticles as biomarkers of stroke: A focus on the value of endothelial- and platelet-derived microparticles.
El-Gamal, Heba; Parray, Aijaz S; Mir, Fayaz A; Shuaib, Ashfaq; Agouni, Abdelali ( Wiley , 2019 , Article)Stroke is one of the leading causes of mortality and disability worldwide. Numerous pathophysiological mechanisms involving blood vessels, coagulation and inflammation contribute to the vascular occlusion. Perturbations ... -
Complement C5a and Clinical Markers as Predictors of COVID-19 Disease Severity and Mortality in a Multi-Ethnic Population
Cyprian, Farhan S.; Suleman, Muhammad; Abdelhafez, Ibrahim; Doudin, Asmma; Masud Danjuma, Ibn Mohammed; Mir, Fayaz Ahmad; Parray, Aijaz; Yousaf, Zohaib; Siddiqui, Mohammed Yaseen Ahmed; Abdelmajid, Alaaedin; Mulhim, Mohammad; Al-Shokri, Shaikha; Abukhattab, Mohammad; Shaheen, Ranad; Elkord, Eyad; Al-khal, Abdul Latif; Elzouki, Abdel Naser; Girardi, Guillermina... more authors ... less authors ( Frontiers Media S.A. , 2021 , Article)Coronavirus disease-2019 (COVID-19) was declared as a pandemic by WHO in March 2020. SARS-CoV-2 causes a wide range of illness from asymptomatic to life-threatening. There is an essential need to identify biomarkers to ... -
Corneal nerve loss in patients with TIA and acute ischemic stroke in relation to circulating markers of inflammation and vascular integrity
Khan, Adnan; Parray, Aijaz; Akhtar, Naveed; Agouni, Abdelali; Kamran, Saadat; Pananchikkal, Sajitha V.; Priyanka, Ruth; Gad, Hoda; Ponirakis, Georgios; Petropoulos, Ioannis N.; Chen, Kuan-Han; Tayyab, Kausar; Saqqur, Maher; Shuaib, Ashfaq; Malik, Rayaz A.... more authors ... less authors ( Nature Research , 2022 , Article)Vascular and inflammatory mechanisms are implicated in the development of cerebrovascular disease and corneal nerve loss occurs in patients with transient ischemic attack (TIA) and acute ischemic stroke (AIS). We have ... -
Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome
Mir, Fayaz Ahmad; Ullah, Ehsan; Mall, Raghvendra; Iskandarani, Ahmad; Samra, Tareq A.; Cyprian, Farhan; Parray, Aijaz; Alkasem, Meis; Abdalhakam, Ibrahem; Farooq, Faisal; Abou-Samra, Abdul Badi... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Background: Obesity coexists with variable features of metabolic syndrome, which is associated with dysregulated metabolic pathways. We assessed potential associations between serum metabolites and features of metabolic ... -
Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders
Abdelsam, Shahenda Salah; Ghanem, Sarah Khalaf; Zahid, Muhammad Ammar; Abunada, Hanan H.; Bader, Loulia; Raïq, Hicham; Khan, Abbas; Parray, Aijaz; Djouhri, Laiche; Agouni, Abdelali... more authors ... less authors ( Wiley , 2024 , Article Review)RNA-binding proteins (RBPs) play a crucial role in the regulation of posttranscriptional RNA networks, which can undergo dysregulation in many pathological conditions. Human antigen R (HuR) is a highly researched RBP that ... -
The impact of enteric coating of aspirin on aspirin responsiveness in patients with suspected or newly diagnosed ischemic stroke: prospective cohort study: results from the (ECASIS) study
Elshafei, Mohamed Nabil; Imam, Yahia; Alsaud, Arwa Ebrahim; Chandra, Prem; Parray, Aijaz; Abdelmoneim, Mohamed S.; Obeidat, Khaldun; Saeid, Razan; Ali, Mohammad; Ayadathil, Raheem; Mohamed, Mouhand F.H.; Abdallah, Ibtihal M.; Mohammed, Shaban; Akhtar, Naveed; Danjuma, Mohammed Ibn Masoud... more authors ... less authors ( Springer Nature , 2022 , Article)Background and purpose: Uncertainty remains regarding the impact of enteric-coated aspirin (EC-ASA) on secondary prevention of ischemic stroke compared to plain aspirin (P-ASA). Hence, this study was designed to investigate ... -
Influence of the Aryl Hydrocarbon Receptor Activating Environmental Pollutants on Autism Spectrum Disorder
Dhulkifle, Hevna; Agouni, Abdelali; Zeidan, Asaad; Al-Kuwari, Mohammed Saif; Parray, Aijaz; Tolefat, Mohamed; Korashy, Hesham M.... more authors ... less authors ( MDPI , 2021 , Article Review)Autism spectrum disorder (ASD) is an umbrella term that includes many different disorders that affect the development, communication, and behavior of an individual. Prevalence of ASD has risen exponentially in the past ... -
Letter to the Editor Response
Abdul, Salam; Kamran, Sadat; Bibi, Rubina; Korashy, Hesham M.; Parray, Aijaz; Mannai, Adbulla Al; Ansari, Abdulrahman Al; Kanikicharla, Krishna Kumar; Gashi, Arta Zogaj; Shuaib, Ashfaq... more authors ... less authors ( Elsevier , 2020 , Other)To the Editor We thank Dr. Luis Rafael Moscote-Salazar and Dr. Amit Agrawal for their interest in our recently published article in the Journal.1 The authors do not raise any concerns about the scientific facts and the ... -
Molecular Mechanisms Underpinning Microparticle-Mediated Cellular Injury in Cardiovascular Complications Associated with Diabetes.
Benameur, Tarek; Osman, Aisha; Parray, Aijaz; Ait Hssain, Ali; Munusamy, Shankar; Agouni, Abdelali... more authors ... less authors ( Hindawi , 2019 , Article)Microparticles (MPs) are small vesicles shed from the cytoplasmic membrane of healthy, activated, or apoptotic cells. MPs are very heterogeneous in size (100-1,000 nm), and they harbor proteins and surface antigens specific ... -
Platelet–Neutrophil Association in NETs-Rich Areas in the Retrieved AIS Patient Thrombi
Pir, Ghulam Jeelani; Parray, Aijaz; Ayadathil, Raheem; Pananchikkal, Sajitha V.; Mir, Fayaz Ahmad; Muhammad, Islam; Abubakar, Ahmed; Amir, Nueman; Hussain, Sohail; Haroon, Khawaja H.; Muhammad, Ahmad; Imam, Yahya; Patro, Satya Narayana; Akhtar, Naveed; Zakaria, Aymen; Kamran, Saadat... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Histological structure of thrombi is a strong determinant of the outcome of vascular recanalization therapy, the only treatment option for acute ischemic stroke (AIS) patients. A total of 21 AIS patients from this study ... -
Sestrin2 as a Protective Shield against Cardiovascular Disease
Zahid, Muhammad Ammar; Abdelsalam, Shahenda Salaheldin; Raïq, Hicham; Parray, Aijaz; Korashy, Hesham Mohamed; Zeidan, Asad; Elrayess, Mohamed A.; Agouni, Abdelali... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)A timely and adequate response to stress is inherently present in each cell and is important for maintaining the proper functioning of the cell in changing intracellular and extracellular environments. Disruptions in the ... -
Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress
Fatima, Munazza T; Hasan, Maram; Abdelsalam, Shahenda S; Sivaraman, Siveen K; El-Gamal, Heba; Zahid, Muhammad A; Elrayess, Mohamed A; Korashy, Hesham M; Zeidan, Asad; Parray, Aijaz S; Agouni, Abdelali... more authors ... less authors ( Elsevier , 2021 , Article)Endoplasmic reticulum (ER) stress is an inflammatory response that contributes to endothelial dysfunction, a hallmark of cardiovascular diseases, in close interplay with oxidative stress. Recently, Sestrin2 (SESN2) emerged ... -
Snornas and mirnas networks underlying covid-19 disease severity
Parray, Aijaz; Mir, Fayaz A.; Doudin, Asmma; Iskandarani, Ahmad; Danjuma, Ibn M.; Kuni, Rahim A.; Abdelmajid, Alaaedin; Abdelhafez, Ibrahim; Arif, Rida; Mulhim, Mohammad; Abukhattab, Mohammad; Dar, Shoukat R.; Moustafa, Ala-Eddin A.; Elkord, Eyad; Al Khal, Abdul L.; Elzouki, Abdel-Naser; Cyprian, Farhan... more authors ... less authors ( MDPI , 2021 , Article)There is a lack of predictive markers for early and rapid identification of disease progression in COVID-19 patients. Our study aims at identifying microRNAs (miRNAs)/small nucleolar RNAs (snoRNAs) as potential biomarkers ... -
There Is Selective Increase in Pro-thrombotic Circulating Extracellular Vesicles in Acute Ischemic Stroke and Transient Ischemic Attack: A Study of Patients From the Middle East and Southeast Asia.
Agouni, Abdelali; Parray, Aijaz S; Akhtar, Naveed; Mir, Fayaz A; Bourke, Paula J; Joseph, Sujata; Morgan, Deborah M; Santos, Mark D; Wadiwala, Muhammad F; Kamran, Saadat; Sivaraman, Siveen K; Shuaib, Ashfaq... more authors ... less authors ( Frontiers Media , 2019 , Article)Stroke attacks were found to be present at a younger age in patients from Southeast Asia (SE) and the Middle East (ME) resident in the state of Qatar. Extracellular vesicles (EVs), which are small membrane vesicles with ...