Browsing by Subject "breast cancer"
Now showing items 41-60 of 61
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Letter to editor/comment : Metaplastic carcinoma of the breast: Prognosis and response to systemic treatment in metastatic disease
( Wiley , 2019 , Other)Comment on the recent paper on metaplastic breast carcinoma study published in the Breast Journal 2019. -
Letter to Editor: Apocrine carcinoma is the fact. Comment on the recent paper entitled "Invasive apocrine carcinoma of the breast: Myth or fact?" by Gurrado et al (Breast J. 2019 Sep 8. doi: 10.1111/tbj.13569. [Epub ahead of print].
( Wiley , 2019 , Article)The most recent WHO classification of breast cancer also recognizes the concept of “pure apocrine carcinoma” (called carcinoma with apocrine differentiation) with cancers having >90% of apocrine morphology (an essential ... -
Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images
( Institute of Electrical and Electronics Engineers Inc. , 2016 , Article)Detection and classification of cell nuclei in histopathology images of cancerous tissue stained with the standard hematoxylin and eosin stain is a challenging task due to cellular heterogeneity. Deep learning approaches ... -
Molecular Profiling of Clear Cell Carcinoma of the Breast Reveals Novel Targetable Biomarkers
( Springer Nature , 2020 , Conference Paper)Background: Although clear cell morphology may be seen in various subtypes of breast cancer, a pure variant of clear cell carcinoma (usually glycogen-rich) is a very rare primary breast malignancy. It is characterized by ... -
Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion
( Wiley Open Access , 2020 , Article)Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. Only 5%-10% of mutations in BRCA genes are associated with familial breast tumours in Eastern countries, suggesting the ... -
Novel targetable biomarkers in clear cell carcinoma of the breast uncovered by molecular profiling: A study of nine cases.
( Wiley , 2020 , Article)We profiled nine pure clear cell carcinomas of the breast using massively parallel DNA and RNA sequencing (NGS), in situ hybridization (ISH), and immunohistochemistry (IHC). All cases were primary mammary clear cell ... -
Oncoproteins of High-Risk HPV and EBV Cooperate to Enhance Cell Motility and Invasion of Human Breast Cancer Cells Erk1/Erk2 and β-Catenin Signaling Pathways.
( Frontiers Media , 2021 , Article)Breast cancer is a leading cause of death in women around the world. Most breast cancer-related deaths are a result of complications from the metastatic spread. Several recent studies reported that high-risk human ... -
Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells
( Frontiers Media , 2022 , Article)Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ... -
PCF11, a Novel CD44-Downstream Transcriptional Target, Linking Its 3'-End Polyadenylation Function to Tumor Cell Metastasis
( Frontiers Media S.A. , 2022 , Article Review)Breast Cancer (BC) is the most common and the major health issue in women worldwide. Metastasis, a multistep process, is the worst aspect of cancer and tumor cell invasion is the defining step. Tumor cell invasion requires ... -
Psychosocial Aspects of Female Breast Cancer in the Middle East and North Africa.
( MDPI , 2020 , Article)Breast cancer, the most common cancer among women in the Middle East and North Africa (MENA) region, is associated with social and psychological implications deriving from women's socio-cultural contexts. Examining 74 ... -
Quality-of-life among women with breast cancer: application of the international classification of functioning, disability and health model
( Frontiers Media SA , 2024 , Article)Background: This study aimed to identify the factors that influence Breast Cancer (BC) women’s quality of life (QoL) based on the International Classification of Functioning, Disability and Health (ICF) framework. Method: ... -
Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor.
( Frontiers Media , 2022 , Article)Immune checkpoint blockade (ICB)-based therapy is revolutionizing cancer treatment by fostering successful immune surveillance and effector cell responses against various types of cancers. However, patients with HER2+ ... -
The Role of CCL21/CCR7 Chemokine Axis in Breast Cancer Progression
( MDPI , 2015 , Article Review)Tumor-induced lymphangiogenesis facilitates breast cancer progression by generating new lymphatic vessels that serve as conduits for tumor dissemination to lymph nodes and beyond. Given the recent evidence suggesting the ... -
Screening Novel Molecular Targets of Metformin in Breast Cancer by Proteomic Approach.
( Frontiers Media , 2017 , Article)Metformin is a commonly prescribed antihyperglycemic drug, and has been investigated in vivo and in vitro for its effect to improve the comorbidity of diabetes and various types of cancers. Several studies investigated the ... -
SIRT1, a novel transcriptional downstream target of CD44, linking its deacetylase activity to tumor cell invasion/metastasis
( Frontiers Media S.A. , 2022 , Short Survey)Our tetracycline-off-inducible CD44 expression system previously established in mouse model, revealed that activation of CD44 with its major ligand hyaluronan (HA) promoted breast cancer (BC) metastasis to the liver. To ... -
Spindle cell carcinoma of the breast: Rare cancer with potentially targetable biomarkers.
( Elsevier , 2019 , Conference Paper)Background Spindle cell carcinoma is a rare, metaplastic breast cancer (<1% of all breast carcinomas), with reportedly triple-negative (TNBC: ER-/PR-/Her2-) phenotype, associated with a marked resistance to conventional ... -
Targeted immunotherapy with a checkpoint inhibitor in combination with chemotherapy: A new clinical paradigm in the treatment of triple-negative breast cancer.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2019 , Article Review)The treatment of several solid and hematologic malignancies with immune checkpoint inhibitors (against PD-1/PD-L1) has dramatically changed the cancer treatment paradigm. However, no checkpoint inhibitors were previously ... -
Targeting HER2 expression in cancer: New drugs and new indications.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2020 , Article)Functional activation of human epidermal growth factor receptor 2 (HER2) has been shown to strongly promote carcinogenesis, leading to the investigation of HER2-directed agents in cancers with HER2 genomic alterations. ... -
Theranostic molecular profiling of pleomorphic ductal carcinoma of the breast.
( Wiley , 2019 , Other)Pleomorphic ductal carcinoma (PDC) is a very rare subtype of invasive ductal carcinoma of no‐special type (NST), characterized by the presence of highly atypical/bizarre (>6‐fold variation in nuclear size) and multinucleated ... -
Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity.
( MDPI , 2019 , Article)Breast cancer is the most frequent cause of cancer-related deaths among women worldwide. It is classified into four major molecular subtypes. Triple-negative breast cancers (TNBCs), a subgroup of breast cancer, are defined ...