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Now showing items 11684-11703 of 49153
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Glucose and transferrin liganded PLGA nanoparticles internalization in non-small cell lung cancer cells
( Qatar University Press , 2020 , Poster)Introduction: Recently, after a decade of confusing results, several studies pointed out that overexpression of GLUT1 (glucose transporter 1) is a biomarker of worse prognosis in NSCLC. Nonetheless, the presence of Transferrin ... -
Glucose- and triglyceride-lowering dietary penta-O-galloyl-α-D-glucose reduces expression of PPARγ and C/EBPα, induces p21-Mediated G1 phase cell cycle arrest, and inhibits adipogenesis in 3T3-L1 preadipocytes
( Thieme , 2015 , Article)Plant polyphenols, such as hydrolysable tannins, are present in the human diet and known to exhibit anti-diabetic and anti-obesity activity. We previously reported that the representative hydrolysable tannin compound ... -
Glycan analysis as biomarkers for testicular cancer
( MDPI AG , 2019 , Article Review)The U.S. Preventive Services Task Force does not recommend routine screening for testicular cancer (TC) in asymptomatic men, essentially because serological testicular cancer (TC) biomarkers are not reliable. The main ... -
Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses.
( Nature Research , 2020 , Article)The conserved hemagglutinin (HA) stem has been a focus of universal influenza vaccine efforts. Influenza A group 1 HA stem-nanoparticles have been demonstrated to confer heterosubtypic protection in animals; however, the ... -
Glycemic index of selected carbohydrate-based foods consumed in Qatar
( Taylor & Francis , 2010 , Article)This study determined the glycemic index (GI) of selected carbohydrate-rich foods consumed in Qatar. Recruited volunteers (n = 19) consumed two reference foods, glucose and white bread, and 10 test foods. The foods tested ... -
Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia
( Public Library of Science (USA) , 2016 , Article)Sideroblastic anemias are acquired or inherited anemias that result in a decreased ability to synthesize hemoglobin in red blood cells and result in the presence of iron deposits in the mitochondria of red blood cell ... -
Glycine improves peritoneal vasoreactivity to dialysis solutions in the elderly
( Hamad Medical Corporation , 2019 , Article)Background: Peritoneal dialysis solution (PDS) dilates peritoneal microvessels predominantly by the activation of the endothelial nitric oxide (NO) pathway. We made an incidental observation of decreased PDS-induced, ... -
Glycogen-rich Clear Cell Carcinoma of the Breast: A Comprehensive Review.
( Lippincott, Williams & Wilkins , 2020 , Article Review)Glycogen-rich clear cell carcinoma (GRCC) is a very rare form of primary breast cancer (<0.1% of all breast cancers). It is characterized by the presence of neoplastic cells with a glycogen-abundant clear cytoplasm (the ... -
Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer
( BMJ Publishing Group , 2020 , Article)Introduction Patients with diabetes have increased risk of periodontal disease, with increased risk of weakening of periodontal ligament and tooth loss. Periodontal ligament is produced and maintained by periodontal ligament ... -
Glycomic and Glycoproteomic Techniques in Neurodegenerative Disorders and Neurotrauma: Towards Personalized Markers
( MDPI , 2022 , Article Review)The proteome represents all the proteins expressed by a genome, a cell, a tissue, or an organism at any given time under defined physiological or pathological circumstances. Proteomic analysis has provided unparalleled ... -
Glycomics meets artificial intelligence – Potential of glycan analysis for identification of seropositive and seronegative rheumatoid arthritis patients revealed
( Elsevier B.V. , 2018 , Article)In this study, one hundred serum samples from healthy people and patients with rheumatoid arthritis (RA) were analyzed. Standard immunoassays for detection of 10 different RA markers and analysis of glycan markers on ... -
Glycomics of prostate cancer: updates
( Taylor and Francis Ltd , 2019 , Article)Introduction: Prostate cancer (PCa) is a life-threatening disease affecting millions of men. The current best PCa biomarker (level of prostate-specific antigen in serum) lacks specificity for PCa diagnostics and this is ... -
Glycoprofiling as a novel tool in serological assays of systemic sclerosis: A comparative study with three bioanalytical methods
( Elsevier , 2015 , Article)Systemic sclerosis (SSc) is an autoimmune disease seriously affecting patient’s quality of life. The heterogeneity of the disease also means that identification and subsequent validation of biomarkers of the disease is ... -
Glycoprofiling of cancer biomarkers: Label-free electrochemical lectin-based biosensors
( De Gruyter , 2015 , Article)Glycosylation of biomolecules is one of the most prevalent post- and co-translational modification in a human body, with more than half of all human proteins being glycosylated. Malignant transformation of cells influences ... -
Glycoside-based niosomal nanocarrier for enhanced in-vivo performance of Cefixime
( Elsevier B.V. , 2016 , Article)This study aimed to evaluate the potential of a novel glycoside non-ionic surfactant synthesized and characterized in our laboratory for increased oral bioavailability of Cefixime. The surfactant was synthesized by simple ... -
Glycosides of Heterocycles: A Direct Route to 1-(β-D-Glycopyranosyl)pyridinethione Nucleosides
( WILEY-VCH Verlag , 1994 , Article)A novel synthesis of 1-(β-d-glycopyranosyl)pyridinethione nucleosides 6 utilizing pyridine-2(1H)-thiones 3 and α-halogeno sugars 4 as starting components is reported. -
Glycosylation is a novel TGF?1-independent post-translational modification of Smad2
( Elsevier B.V. , 2019 , Article)Smad2 is a crucial component of intracellular signaling by transforming growth factor-? (TGF?). Here we describe that Smad2 is glycosylated, which is a novel for Smad2 post-translational modification. We showed that the ... -
Goal programming for financial portfolio management: a state-of-the-art review
( Springer Nature , 2017 , Article)Over the last decades, the Goal Programming (GP) model has been applied to financial portfolio management and/or selection problem in decision-making contexts where several conflicting and incommensurable objectives are ... -
A Goal Programming Model for Capital Rationing with a Linear Cash Fluctuations Measure
( Qatar University , 1997 , Article) -
Goal programming model for management accounting and auditing: a new typology
( Springer New York LLC , 2017 , Article)In practice, generally the accountants are facing complex decision-making situations where they aggregate simultaneously several conflicting and incommensurable factors (dimensions). They look for the decision of the best ...