Browsing by Subject "Biomarkers"
Now showing items 1-20 of 32
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A smartphone-interfaced, low-cost colorimetry biosensor for selective detection of bronchiectasis via an artificial neural network
( Royal Society of Chemistry , 2022 , Article)Exhaled breath (EB) contains several macromolecules that can be exploited as biomarkers to provide clinical information about various diseases. Hydrogen peroxide (H2O2) is a biomarker because it indicates bronchiectasis ... -
Biofluid proteomics and biomarkers in traumatic brain injury
( Humana Press Inc. , 2017 , Book chapter)Traumatic brain injury (TBI) is an injury to the brain caused by an external mechanical force, affecting millions of people worldwide. The disease course and prognosis are often unpredictable, and it can be challenging to ... -
Bioinformatics investigation on blood-based gene expressions of Alzheimer's disease revealed ORAI2 gene biomarker susceptibility: An explainable artificial intelligence-based approach
( Springer , 2023 , Article)The progressive, chronic nature of Alzheimer's disease (AD), a form of dementia, defaces the adulthood of elderly individuals. The pathogenesis of the condition is primarily unascertained, turning the treatment efficacy ... -
BRIP1 overexpression is correlated with clinical features and survival outcome of luminal breast cancer subtypes
( BioScientifica Ltd. , 2018 , Article)In Oman, breast cancer is most common, representing approximately more than 25% of all cancers in women. Relatively younger populations of patients (25-40 years) present surprisingly with an aggressive phenotype and advanced ... -
Can atorvastatin with metformin change the natural history of prostate cancer as characterized by molecular, metabolomic, imaging and pathological variables? A randomized controlled trial protocol
( Elsevier , 2016 , Article)Background Atorvastatin and metformin are known energy restricting mimetic agents that act synergistically to produce molecular and metabolic changes in advanced prostate cancer (PCa). This trial seeks to determine whether ... -
Cerebrospinal fluid α-synuclein species in cognitive and movements disorders
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Total CSF α-synuclein (t-α-syn), phosphorylated α-syn (pS129-α-syn) and α-syn oligomers (o-α-syn) have been studied as candidate biomarkers for synucleinopathies, with suboptimal specificity and sensitivity in the ... -
Corneal nerve loss in patients with TIA and acute ischemic stroke in relation to circulating markers of inflammation and vascular integrity
( Nature Research , 2022 , Article)Vascular and inflammatory mechanisms are implicated in the development of cerebrovascular disease and corneal nerve loss occurs in patients with transient ischemic attack (TIA) and acute ischemic stroke (AIS). We have ... -
Development and Validation of an Early Scoring System for Prediction of Disease Severity in COVID-19 Using Complete Blood Count Parameters
( Institute of Electrical and Electronics Engineers Inc. , 2021 , Article)The coronavirus disease 2019 (COVID-19) after outbreaking in Wuhan increasingly spread throughout the world. Fast, reliable, and easily accessible clinical assessment of the severity of the disease can help in allocating ... -
Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications.
( Elsevier , 2020 , Article Review)The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor ... -
Exploring serum glycome patterns after moderate to severe traumatic brain injury: A prospective pilot study
( Elsevier , 2022 , Article)BackgroundGlycans play essential functional roles in the nervous system and their pathobiological relevance has become increasingly recognized in numerous brain disorders, but not fully explored in traumatic brain injury ... -
Finding Behavioural and Imaging Biomarkers of Major Depressive Disorder (MDD) using Artificial Intelligence: A Review
( Institute of Electrical and Electronics Engineers Inc. , 2020 , Conference Paper)Major Depressive Disorder (MDD) is a serious ailment in mental health and is a medical illness that has a debilitating impact on a person's ability to think effectively. According to the World Health Organization (WHO), ... -
Gene expression and miRNAs profiling: Function and regulation in human epidermal growth factor receptor 2 (HER2) - positive breast cancer
( MDPI AG , 2019 , Article)Breast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 ... -
Geochemical investigation of Yamama crude oils and their inferred source rocks in the Mesopotamian Basin, Southern Iraq
( Taylor & Francis , 2019 , Article)Ten oil samples from the Yamama reservoirs and ten extracts of purported source rocks from sixteen wells in the Mesopotamian Basin, Southern Iraq have been analyzed using GC, GC/MS and Stable Carbon Isotope. Yamama oils ... -
Geochemical investigation of Yamama crude oils and their inferred source rocks in the Mesopotamian Basin, Southern Iraq
( Taylor and Francis Inc. , 2019 , Article)Ten oil samples from the Yamama reservoirs and ten extracts of purported source rocks from sixteen wells in the Mesopotamian Basin, Southern Iraq have been analyzed using GC, GC/MS and Stable Carbon Isotope. Yamama oils ... -
Glycan analysis as biomarkers for testicular cancer
( MDPI AG , 2019 , Article Review)The U.S. Preventive Services Task Force does not recommend routine screening for testicular cancer (TC) in asymptomatic men, essentially because serological testicular cancer (TC) biomarkers are not reliable. The main ... -
The identification of highly upregulated genes in claudin-low breast cancer through an integrative bioinformatics approach
( Elsevier , 2020 , Article)Breast cancer (BC) is one of the leading causes of cancer-related death among women worldwide, and claudin-low breast cancer (CLBC) is a subtype of BC that remains poorly described. This study aimed to identify upregulated ... -
Imaging cancer cells with nanostructures: Prospects of nanotechnology driven non-invasive cancer diagnosis
( Elsevier B.V. , 2021 , Article)The application of nanostructured materials in medicine is a rapidly evolving area of research that includes both the diagnosis and treatment of various diseases. Metals, metal oxides and carbon-based nanomaterials have ... -
Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview
( Elsevier , 2023 , Article)Given the ambiguity surrounding traumatic brain injury (TBI) pathophysiology and the lack of any Food and Drug Administration (FDA)-approved neurotherapeutic drugs, there is an increasing need to better understand the ... -
Integrated datasets of proteomic and metabolomic biomarkers to predict its impacts on comorbidities of type 2 diabetes mellitus
( Dove Medical Press , 2020 , Article)© 2020 Cheema et al. Objective: The objective of the current study is to accomplish a relative exploration of the biological roles of differentially dysregulated genes (DRGs) in type 2 diabetes mellitus (T2DM). The study ... -
Investigation of differentially expressed genes and dysregulated pathways involved in multiple sclerosis
( Elsevier , 2022 , Book chapter)Multiple Sclerosis (MS) is a neurodegenerative autoimmune and organ-specific demyelinating disorder, known to affect the central nervous system (CNS). While genetic studies have revealed several critical genes and diagnostic ...