Browsing by Subject "metabolism"
Now showing items 1-20 of 27
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Analysis of the Qatari R336C Cystathionine β-Synthase Protein in Mice.
( Wiley , 2019 , Article)Classical homocystinuria is a recessive inborn error of metabolism caused by mutations in the cystathionine beta-synthase (CBS) gene. The highest incidence of CBS deficiency in the world is found in the country of Qatar ... -
BIAN N-heterocyclic gold carbene complexes induced cytotoxicity in human cancer cells via upregulating oxidative stress
( Asian Pacific Organization for Cancer Prevention , 2015 , Article)Background: Nanoparticles of gold and silver are offering revolutionary changes in the field of cancer therapy. N-heterocyclic carbene (NHC) metal complexes possess diverse biological activities and are being investigated ... -
Consequences of a Great Crisis on Chronic Diseases: How Childhood Exposures May Shape Future Health
( John Wiley and Sons Inc , 2021 , Article)[No abstract available] -
Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors
( Elsevier Masson SAS , 2016 , Article)A novel series of substituted chalcones were designed and synthesized to be evaluated as selective human MAO-B inhibitors. A combination of either methylsulfonyl or trifluoromethyl substituents on the aromatic ketone moiety ... -
Detection of Paracetamol as substrate of the gut microbiome
( University of Karachi, Pharmacy College , 2019 , Article)Gut microbiome, a new organ; represent targets to alter pharmacokinetics of orally administered drugs. Recently, in vitro trials endorsed the idea that orally administered drugs interact and some of their quantity may be ... -
Docosahexaenoic Acid Counteracts the Hypoxic-Induced Inflammatory and Metabolic Alterations in 3T3-L1 Adipocytes
( MDPI , 2022 , Article)Background: Hypoxia is caused by the excessive expansion of the white adipose tissue (AT) and is associated with obesity-related conditions such as insulin resistance, inflammation, and oxidative stress. Docosahexaenoic ... -
Effect of recombinant human erythropoietin and doxorubicin in combination on the proliferation of MCF-7 and MDA-MB231 breast cancer cells
( Spandidos Publications , 2016 , Article)Patients with cancer often exhibit signs of anemia as the result of the disease. Thus, cancer chemotherapies often include erythropoietin (EPO) in the regime to improve the survival rate of these patients. The aim of the ... -
Fuzzy intervention in biological phenomena
( IEEE , 2012 , Article)An important objective of modeling biological phenomena is to develop therapeutic intervention strategies to move an undesirable state of a diseased network toward a more desirable one. Such transitions can be achieved by ... -
Genotype-phenotype correlation in patients with isovaleric acidaemia: comparative structural modelling and computational analysis of novel variants.
( Oxford University Press (OUP) , 2017 , Article)Isovaleric acidaemia (IVA) is an autosomal recessive inborn error of leucine metabolism. It is caused by a deficiency in the mitochondrial isovaleryl-CoA dehydrogenase (IVD) enzyme. In this study, we investigated eight ... -
Glucocorticoid-induced fetal origins of adult hypertension: Association with epigenetic events
( Elsevier Inc. , 2016 , Article Review)Hypertension is a predominant risk factor for cardiovascular diseases and a major health care burden. Accumulating epidemiological and experimental evidence suggest that adult-onset hypertension may have its origins during ... -
High-intensity exercise training does not influence body weight but improves lipid oxidation in obese adults: A 6-week RCT
( BMJ Publishing Group , 2017 , Article)Objectives This study examined the effects of 6 weeks of high-intensity training (HIT) on lipid oxidation (LO) rates during incremental exercises in obese adults. Methods Twenty-four obese adults were randomised into a ... -
Highly ordered nanoporous carbon films with tunable pore diameters and their excellent sensing properties
( Wiley-VCH Verlag , 2015 , Article)Ordered porous carbon films with tunable pore diameters, immobilized with glucose oxidase (GOD) have been fabricated and employed for the construction of a biosensor for glucose molecules. The as-prepared porous films have ... -
Human microbiome and its association with health and diseases
( Wiley , 2016 , Article)Human microbiota are distinct communities of microorganisms that resides at different body niches. Exploration of the human microbiome has become a reality due to the availability of powerful metagenomics and metatranscriptomic ... -
In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway
( Elsevier , 2023 , Article)Background: Cutaneous T cell lymphoma (CTCL) is a T cell-derived non-Hodgkin lymphoma primarily affecting the skin, with treatment posing a significant challenge and low survival rates. Objective: In this study, we ... -
Instrumentation of Flow-Through USP IV Dissolution Apparatus to Assess Poorly Soluble Basic Drug Products: a Technical Note
( Springer New York LLC , 2016 , Article)Supersaturation and precipitation are common limitations encountered especially with poorly soluble basic drugs. The aims of this work were to explore the pattern of dissolution and precipitation of poorly soluble basic ... -
Magnetic mesoporous nanospheres anchored with LyP-1 as an efficient pancreatic cancer probe
( Elsevier Ltd , 2017 , Article)Immobilization of a ligand that selectively interacts with cancer cells to nanomaterials can enhance their diagnostic and therapeutic efficiency. In this study, we firstly demonstrate the high expression of receptor for ... -
Metabolic aspects of surgical subcutaneous fat removal: an umbrella review and implications for future research.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2022 , Article Review)Although obesity is a preventable disease, maintaining a normal body weight can be very challenging and difficult, which has led to a significant increase in the demand for surgical subcutaneous fat removal (SSFR) to improve ... -
Metabolic Effects Of Cyproterone Acetate And Corticosterone In The Chicken Callus Domesticus
( Qatar University , 1990 , Article)The metabolic effects of corticosterone were compared with those of cyproterone acetate , a steroidogenic inhibitor with suggested corticoid-like effects. Corticosterone significantly increased serum levels of ... -
miR-21 mimic blocks obesity in mice: A novel therapeutic option
( Elsevier , 2021 , Article)MicroRNAs (miRNAs) are promising drug targets for obesity and metabolic disorders. Recently, miRNA mimics are providing a unique mechanism of action that guides the process for drug development and sets out the context of ... -
Multiscale structural evolution of citrate-triggered intrafibrillar and interfibrillar mineralization in dense collagen gels
( Academic Press Inc. , 2020 , Article)The mineralized extracellular matrix of bone is an organic?inorganic nanocomposite consisting primarily of carbonated hydroxyapatite, fibrous type I collagen, noncollagenous proteins, proteoglycans, and diverse biomolecules ...