Browsing by Subject "Metastasis"
Now showing items 1-17 of 17
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Anti-Metastatic and Anti-Tumor Growth Effects of Origanum majorana on Highly Metastatic Human Breast Cancer Cells: Inhibition of NFκB Signaling and Reduction of Nitric Oxide Production
( Public Library of Science , 2013 , Article)Background: We have recently reported that Origanum majorana exhibits anticancer activity by promoting cell cycle arrest and apoptosis of the metastatic MDA-MB-231 breast cancer cell line. Here, we extended our study by ... -
Bioengineered microfluidic blood-brain barrier models in oncology research
( Neoplasia Press, Inc. , 2021 , Article)Metastasis is the major reason for most brain tumors with up to a 50% chance of occurrence in patients with other types of malignancies. Brain metastasis occurs if cancer cells succeed to cross the ?blood-brain barrier? ... -
Breast carcinoma metastasis suppressor gene 1 (BRMS1): update on its role as the suppressor of cancer metastases.
( Springer , 2015 , Article)BRMS1 was discovered over a decade ago as a potential tumor suppressor gene. In this review, we summarize the recent findings about the structure of BRMS1, mechanisms of its action and a role of BRMS1 in the cancer ... -
Cancer Metastasis: Dynamic Hetero-cellular Communications Between Cancer Cells and Host Tissues
( Springer International Publishing , 2023 , Book chapter)Metastasis is the most devastating aspect of cancer. Originally, tumor cells arise from a single clone, and then they undergo additional mutations and acquire invasive and metastatic features. These acquired mutations are ... -
CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion.
(2017 , Article)We have previously validated three novel CD44-downstream positively regulated transcriptional targets, including Cortactin, Survivin and TGF-β2, and further characterized the players underlying their separate signaling ... -
Chemokine-cytokine networks in the head and neck tumor microenvironment
( MDPI , 2021 , Article Review)Head and neck squamous cell carcinomas (HNSCCs) are aggressive diseases with a dismal patient prognosis. Despite significant advances in treatment modalities, the five-year survival rate in patients with HNSCC has improved ... -
Choroidal metastasis as initial presentation of aggressive medullary thyroid carcinoma with widespread mediastinal, brain, pituitary, bone, lung, and liver metastasis: Case report and literature review
( Elsevier , 2021 , Article)Introduction Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that originates from the parafollicular C cells of the thyroid gland. MTC can be due to sporadic or hereditary causes due to gain of function germ ... -
Composition of the immune microenvironment differs between carcinomas metastatic to the lungs and primary lung carcinomas.
( Elsevier , 2018 , Article)Lungs are among the most common sites for development of both primary and metastatic carcinomas. Tumor cells expression (TC) of PD-L1 is an important predictor of the of response to immune check-point inhibition in NSCLC, ... -
A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds (Sesamum indicum).
( Elsevier , 2017 , Article)Sesamin is the major active ingredient is Sesamum indicum seeds. Several studies revealed that sesamin possesses potent anti-cancer properties. The anti-cancer effects of sesamin have been mainly attributed to its ... -
Contribution of Glycosaminoglycan binding in CCL21-mediated Migration of Breast Cancer cells
( Qatar University Press , 2021 , Poster)Lymph node metastasis constitutes a key event in Breast Cancer progression and it is a process at least partially mediated by the chemokine CCR7. Chemokine function is dependent upon their binding to both cell-surface ... -
Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance.
( Springer Verlag , 2019 , Article)The tumor microenvironment represents a complex network, in which tumor cells not only communicate with each other but also with stromal and immune cells. Current research has demonstrated the vital role of the tumor ... -
Impact of heparan sulphate binding domain of chemokine CCL21 to migration of breast cancer cells
( Qatar University Press , 2020 , Poster)Lymph node metastasis constitutes a key event in breast cancer progression. Chemokines are small proteins, which can promote metastatic spread by inducing cancer cell migration and invasion. Chemokine function is dependant ... -
Intercellular Communication in Cancer
( Springer , 2023 , Book chapter)Junctional complexes play a central role in maintaining tissue hemostasis. The barrier function of epithelial cells, that maintain tissues coherence and coordination of cellular synchronicity, is a consequence of a junctional ... -
Long non-coding RNAs regulated NF-κB signaling in cancer metastasis: Micromanaging by not so small non-coding RNAs
( Elsevier Ltd. , 2022 , Article)Cancer metastasis is a major reason for the cancer-associated deaths and a role of long non-coding RNAs (lncRNAs) in cancer metastasis is increasingly being realized. Among the many oncogenic pathways, NF-κB signalling’s ... -
RKIP in human diseases and its potential as a prognostic indicator and therapeutic target
( Elsevier , 2020 , Book chapter)The Raf kinase inhibitory protein (RKIP) is an inhibitor of the RAF/MEK/ERK and NF-κB signaling pathways, through which it regulates several key processes of the cell's physiology, such as its proliferation, motility and ... -
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance.
( BMC , 2020 , Article Review)Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia ... -
Snornas and mirnas networks underlying covid-19 disease severity
( MDPI , 2021 , Article)There is a lack of predictive markers for early and rapid identification of disease progression in COVID-19 patients. Our study aims at identifying microRNAs (miRNAs)/small nucleolar RNAs (snoRNAs) as potential biomarkers ...