تصفح Medicine Research حسب العنوان
السجلات المعروضة 1254 -- 1273 من 1337
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Towards Molecular Profiling in Multiple Myeloma: A Literature Review and Early Indications of Its Efficacy for Informing Treatment Strategies.
( MDPI , 2018 , Article)Multiple myeloma (MM), the second most common hematologic malignancy, is characterized by the clonal expansion of plasma cells. Despite dramatic improvements in patients' survival over the past decade due to advances in ... -
Towards the Pharmacological Validation and Phytochemical Profiling of the Decoction and Maceration of Bruguiera gymnorhiza (L.) Lam.-A Traditionally Used Medicinal Halophyte
( MDPI , 2022 , Article)Decoctions (leaves and roots) of Bruguiera gymnorhiza (L.) Lam. are traditionally used against diabetes in many countries, including Mauritius. This study endeavoured to evaluate the inhibitory potential of leaves, roots, ... -
Tranexamic Acid for Traumatic Injury in the Emergency Setting: A Systematic Review and Bias-Adjusted Meta-Analysis of Randomized Controlled Trials
( Elsevier , 2024 , Article)Study objectiveTraumatic injury causes a significant number of deaths due to bleeding. Tranexamic acid (TXA), an antifibrinolytic agent, can reduce bleeding in traumatic injuries and potentially enhance outcomes. Previous ... -
Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model
( MDPI , 2022 , Article)Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart’s contractile machinery. To investigate ... -
Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease.
( American Heart Association , 2020 , Article)N/A -
Transforming growth factor-β1 inhibits interleukin-1β-induced expression of inflammatory genes and Cathepsin S activity in human vascular smooth muscle cells
( John Wiley and Sons Inc , 2021 , Article)Objective and design This study investigated the opposite mechanisms by which IL-1β and TGF-β1 modulated the inflammatory and migratory phenotypes in cultured human intimal vascular smooth muscle cells vSMCs. Materials ... -
Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy
( BioMed Central Ltd , 2023 , Article)Background: The mechanism of tumor immune escape and progression in colorectal cancer (CRC) is widely investigated in-vitro to help understand and identify agents that might play a crucial role in response to treatment and ... -
Trends in prescribing and outcomes in obese versus non-obese patients receiving rivaroxaban therapy: an observational study using real-world data
( Springer Science and Business Media Deutschland GmbH , 2023 , Article)Purpose To investigate real-world prescribing trends and clinical outcomes based on body mass index (BMI) categorization in patients who received rivaroxaban therapy. Methods This was a retrospective cohort study ... -
Trends in prevalence of depression and anxiety symptoms and effects of sociodemographic variables before and after the first wave of COVID-19 in Qatar
( Elsevier , 2022 , Article)Background Prevalence trends from Arabic speaking countries on psychiatric symptoms before and after the first wave of the COVID-19 pandemic are lacking. We estimated the point prevalence and change in depression and ... -
Triage of referrals in a child and adolescent mental health service in Qatar: Reducing waiting times and promoting needs-based prioritisation
( Cambridge University Press , 2021 , Article)This paper summarises the impact of a new triage process on referral prioritisation and waiting times in a community specialist child and adolescent mental health service (CAMHS) in Qatar. The process involves initial ... -
Trilayer composite scaffold for urethral reconstruction: in vitro evaluation of mechanical, biological, and angiogenic properties
( IOP Publishing , 2024 , Article)Regeneration of damaged urethral tissue remains a major challenge in the field of lower urinary tract reconstruction. To address this issue, various synthetic and natural biodegradable biomaterials are currently being ... -
Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity.
( MDPI , 2019 , Article)Breast cancer is the most frequent cause of cancer-related deaths among women worldwide. It is classified into four major molecular subtypes. Triple-negative breast cancers (TNBCs), a subgroup of breast cancer, are defined ... -
Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in mice and women through a nitric oxide-dependent mechanism
( Elsevier , 2020 , Article)Objectives: A previous pilot study showed that pravastatin supplementation improved pregnancy outcomes in women with obstetric antiphospholipid syndrome (OAPS) that developed placental insufficiency despite standard of ... -
Trop-2 protein as a therapeutic target: A focused review on Trop-2-based antibody-drug conjugates and their predictive biomarkers
( Association of Basic Medical Sciences of FBIH , 2022 , Article)Antibody-drug conjugates represent a new class of highly potent antineoplastic drugs built by attaching a small molecule of an anticancer drug (payload) or another therapeutic agent to an antibody recognizing an epitope ... -
Tumor-Type Agnostic, Targeted Therapies: BRAF Inhibitors Join the Group
( Academy of Sciences and Arts of Bosnia and Herzegovina , 2022 , Article)In the present review, we briefly discuss the breakthrough advances in precision medicine using a tumor-agnostic approach and focus on BRAF treatment modalities, the mechanisms of resistance and the diagnostic approach in ... -
Twisting of a Giant Cystic Meckel's Diverticulum in a Toddler: A Case Report and Brief Literature Review
( University Clinical Hospital Tuzla , 2022 , Article)Objective: Herein we report an unusual case of torsed giant cystic Meckel's diverticulum (MD) in a three-year-old boy, il-lustrating the rarity of this condition and briefly reviewing the literature on it. Case Report: A ... -
Typical and atypical carcinoid tumors of the lung: A Clinicopathological correlation of 783 cases with Emphasis on histological features
( Elsevier , 2020 , Article)ABSTRACT We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and ... -
Ultrasound controlled paclitaxel releasing system—A novel method for improving the availability of coronary artery drug coated balloon
( Wiley , 2020 , Article)Objectives: The aim of this study is to improve local-drug delivery efficiency and tissue absorption using the ultrasound (US)-responsible drug coating based on a newly developed US-controlled paclitaxel release balloon. ... -
Ultrasound diagnosis of infections in pregnancy
( Elsevier , 2021 , Article)Pregnancy is a unique period in which several changes occur in the mother, to ensure that the semiallograft fetus is not rejected. Some of these changes decrease the immunity of the mother to infections. As such, some ... -
Ultrasound Intima-Media Complex (IMC) Segmentation Using Deep Learning Models
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Common carotid intima-media thickness (CIMT) is a common measure of atherosclerosis, often assessed through carotid ultrasound images. However, the use of deep learning methods for medical image analysis, segmentation and ...
