Browsing Medicine Research by Title
Now showing items 190-209 of 1337
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Cardiac autonomic neuropathy: A progressive consequence of chronic low-grade inflammation in type 2 diabetes and related metabolic disorders
( MDPI , 2020 , Article Review)Cardiac autonomic neuropathy (CAN) is one of the earliest complications of type 2 diabetes (T2D), presenting a silent cause of cardiovascular morbidity and mortality. Recent research relates the pathogenesis of cardiovascular ... -
Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats
( Frontiers Media S.A. , 2022 , Article)Background: Doxorubicin as an anti-cancer drug causes cardiotoxicity, limiting its tolerability and use. The mechanism of toxicity is due to free radical production and cardiomyocytes injury. This research evaluated Rheum ... -
Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats
( Frontiers Media SA , 2023 , Article)Introduction: Oxidative stress is a major instigator of various cardiovascular diseases, including myocardial infarction (MI). Despite available drugs, there is still an increased need to look for alternative therapies or ... -
Cardiovascular risk assessment for patients with serious mental illnesses: An internal review
( Hamad bin Khalifa University Press (HBKU Press) , 2021 , Article)Cardiovascular diseases (CVD) are the leading cause of excess premature mortality among patients with serious mental illness (SMI), mainly because of higher cardiovascular risk and metabolic syndrome compared to the general ... -
Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells
( Frontiers , 2022 , Article)We recently reported that carnosol induces ROS-dependent autophagy and apoptosis in breast cancer cells. We also reported that carnosol inhibits breast cancer cell migration, invasion, and in ovo tumor growth, as well as ... -
Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer
( Frontiers Media S.A. , 2021 , Article)Carnosol, a natural polyphenol abundant in edible plants such as sage, rosemary, and oregano, has shown promising anticancer activity against various types of cancers. Nonetheless, very little is known about its molecular ... -
CCN3, POSTN, and PTHLH as potential key regulators of genomic integrity and cellular survival in iPSCs
( Frontiers Media SA , 2024 , Article)Reprogramming human somatic cells into a pluripotent state, achieved through the activation of well-defined transcriptional factors known as OSKM factors, offers significant potential for regenerative medicine. While OSKM ... -
Cell shortening and calcium dynamics in epicardial and endocardial myocytes from the left ventricle of Goto-Kakizaki type 2 diabetic rats
( Blackwell Publishing Ltd , 2018 , Article)New Findings: What is the central question of this study? To investigate haemodynamic dysfunction in the type 2 diabetic Goto-Kakizaki (GK) rat, we measured shortening and Ca2+ transport in ventricular myocytes from ... -
Cell-based diagnostic of bronchial carcinoma: Case study of a diagnostic value of tests of circulating tumor cells and organoid culture
( Danylo Halytskyi Lviv National Medical University , 2020 , Article)Diagnostic based on analysis of living tumor cells is frequently used in oncology. Circulating tumor cells in the blood and cells obtained from a tumor biopsy are used to access their carcinogenic properties and subsequently ... -
Cellular and molecular targets of menthol actions
( Frontiers Media S.A. , 2017 , Article Review)Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, ... -
Cerebrospinal fluid α-synuclein species in cognitive and movements disorders
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Total CSF α-synuclein (t-α-syn), phosphorylated α-syn (pS129-α-syn) and α-syn oligomers (o-α-syn) have been studied as candidate biomarkers for synucleinopathies, with suboptimal specificity and sensitivity in the ... -
Cerebrospinal α-Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort
( Wiley , 2021 , Article)Background: Tangible efforts have been made to identify biomarkers for Parkinson's disease (PD) diagnosis and progression, with α-synuclein (α-syn) related biomarkers being at the forefront. Objectives: The objectives of ... -
Challenges in timing and mode of delivery in morbidly obese women
( Elsevier , 2023 , Article)Globally obesity is increasing especially in the reproductive age group. Pregnant women with obesity have higher complication and intervention rates. They are also at increased risk of stillbirth and intrapartum complications. ... -
Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy
( Elsevier , 2020 , Article)Diabetic peripheral neuropathic pain (DPNP), the most debilitating complication of diabetes mellitus, is resistant to current therapy. The pathogenesis of DPNP is still elusive, but several mechanisms have been proposed ... -
Changing Trends in the Referral and Timing of Treatment for Congenital Cryptorchidism: A Single-Center Experience from Bosnia and Herzegovina.
( Elsevier , 2019 , Article)Cryptorchidism is the most common male urogenital tract disorder identified at birth. Treatment delays of cryptorchidism may be associated with significant complications such as subfertility and testicular cancer. The ... -
Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics
( Elsevier , 2021 , Article)BackgroundAlzheimer's Disease (AD) is a complex and multifactorial disease and novel approaches are needed to illuminate the underlying pathology. Metabolites comprise the end-product of genes, transcripts, and protein ... -
Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome.
( Frontiers , 2022 , Article)Obesity-associated dysglycemia is associated with metabolic disorders. MicroRNAs (miRNAs) are known regulators of metabolic homeostasis. We aimed to assess the relationship of circulating miRNAs with clinical features in ... -
Characteristics of 100 consecutive patients with COVID-19 referred to consultation-liaison psychiatry services in Qatar: A comparison of patients with delirium versus other psychiatric diagnoses
( HBKU Press , 2022 , Article)Introduction: Coronavirus disease 2019 (COVID-19) can present with various neuropsychiatric manifestations. This study reports on patients with COVID19 who were referred to the consultation-liaison (CL) psychiatry services ... -
Characterization and anti-acute T cell leukemia properties of silver nanoparticles synthesized by a green approach for bioremediation applications: Introducing a new chemotherapeutic drug for clinical trial studies
( Wiley , 2020 , Article)© 2020 John Wiley & Sons, Ltd. In recent years, biosynthesis of silver nanoparticles using plant extracts and bioactive compounds has gained much attention. Green synthesis of nanoparticles is eco-friendly, cost-effective, ... -
Characterization and assessment of potential microRNAs involved in phosphate-induced aortic calcification
( Wiley-Liss Inc. , 2018 , Article)Medial artery calcification, a hallmark of type 2 diabetes mellitus and chronic kidney disease (CKD), is known as an independent risk factor for cardiovascular mortality and morbidity. Hyperphosphatemia associated with CKD ...