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Visfatin : An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases
(
Wiley
, 2021 , Article)
Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been implicated in vascular remodeling, vascular ...
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms
(
Elsevier
, 2022 , Article)
Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants have attracted attention as emerging therapeutic ...
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Traumatic Brain Injury?
(
Springer Singapore
, 2022 , Book chapter)
Traumatic brain injury (TBI) is one of the key causes of deaths and disabilities worldwide. TBI progresses in two phases. The primary phase of injury is the direct result of the physical damage caused by the external force ...
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Alzheimer’s Disease?
(
Springer Singapore
, 2022 , Book chapter)
Alzheimer’s disease (AD) is a debilitating neurodegenerative disease with devastating outcomes to patients and exhaustive burdens to healthcare systems. Alzheimer’s disease has always been the focus of extensive research ...
Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells
(
Frontiers Media
, 2022 , Article)
Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ...
2-Nucleobase-substituted 4,6-Diaminotriazine Analogs: Synthesis and Anti-cancer Activity in 5-Fluorouracil-Sensitive and Resistant Colorectal Cancer Cells.
(
Bentham Science Publishers
, 2022 , Article)
Cancer continues to be the second leading cause of death worldwide with colorectal cancer (CRC) being the third most common type. Despite significant advances in cancer therapies, current treatment of CRC remains suboptimal. ...
Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview
(
Elsevier
, 2023 , Article)
Given the ambiguity surrounding traumatic brain injury (TBI) pathophysiology and the lack of any Food and Drug Administration (FDA)-approved neurotherapeutic drugs, there is an increasing need to better understand the ...
Nanoparticles: Attractive tools to treat colorectal cancer
(
Elsevier
, 2022 , Article)
Colorectal Cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Despite the notable advances achieved over the last few decades, CRC remains a hard-to-treat deadly disease in many patients. This ...
G protein estrogen receptor as a potential therapeutic target in Raynaud’s phenomenon
(
Frontiers Media
, 2022 , Article)
Exaggerated cold-induced vasoconstriction can precipitate a pathogenesis called Raynaud’s phenomenon (RP). Interestingly, RP is significantly more prevalent in females than age-matched men, highlighting the potential ...
High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury
(
Elsevier
, 2023 , Article)
AimsTraumatic brain injury (TBI) constitutes a serious public health concern. Although TBI targets the brain, it can exert several systemic effects which can worsen the complications observed in TBI subjects. Currently, ...