Browsing by Author "Posadino, Anna Maria"
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An updated overview of cyanidins for chemoprevention and cancer therapy
Posadino, Anna Maria; Giordo, Roberta; Ramli, Iman; Zayed, Hatem; Nasrallah, Gheyath K.; Wehbe, Zena; Eid, Ali H.; Gürer, Eda Sönmez; Kennedy, John F.; Aldahish, Afaf Ahmed; Calina, Daniela; Razis, Ahmad Faizal Abdull; Modu, Babagana; Habtemariam, Solomon; Sharifi-Rad, Javad; Pintus, Gianfranco; Cho, William C.... more authors ... less authors ( Elsevier , 2023 , Article Review)Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long time. The ... -
Antioxidant Activity Mediates Pirfenidone Antifibrotic Effects in Human Pulmonary Vascular Smooth Muscle Cells Exposed to Sera of Idiopathic Pulmonary Fibrosis Patients.
Fois, Alessandro Giuseppe; Posadino, Anna Maria; Giordo, Roberta; Cossu, Annalisa; Agouni, Abdelali; Rizk, Nasser Moustafa; Pirina, Pietro; Carru, Ciriaco; Zinellu, Angelo; Pintus, Gianfranco... more authors ... less authors ( Hindawi Publishing Corporation , 2018 , Article)Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by an exacerbated fibrotic response. Although molecular and cellular determinants involved in the onset and progression of this devastating disease ... -
Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells
Giordo, Roberta; Cossu, Annalisa; Porcu, Maria Cristina; Cappuccinelli, Roberto; Biosa, Grazia; Sharifi-Rad, Javad; Pretti, Luca; Nasrallah, Gheyath K.; Pintus, Gianfranco; Posadino, Anna Maria... more authors ... less authors ( Taylor & Francis , 2022 , Article)Green chemistry is a useful tool for producing valuable chemicals from biomass. However, extracted compounds need to be tested for safety and efficacy before their use in humans. Here we investigate the chemical composition ... -
Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations.
Ramli, Iman; Posadino, Anna Maria; Giordo, Roberta; Fenu, Grazia; Fardoun, Manal; Iratni, Rabah; Eid, Ali H; Zayed, Hatem; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2023 , Article Review)Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts ... -
Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival.
Posadino, Anna Maria; Giordo, Roberta; Cossu, Annalisa; Nasrallah, Gheyath K; Shaito, Abdullah; Abou-Saleh, Haissam; Eid, Ali H; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2019 , Article)Dietary intake of natural antioxidants is thought to impart protection against oxidative-associated cardiovascular diseases. Despite many in vivo studies and clinical trials, this issue has not been conclusively resolved. ... -
NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs
Posadino, Anna Maria; Erre, Gian Luca; Cossu, Annalisa; Emanueli, Costanza; Eid, Ali H.; Zinellu, Angelo; Pintus, Gianfranco; Giordo, Roberta... more authors ... less authors ( Walter de Gruyter , 2022 , Article)Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial damage and ... -
Nose-to-brain delivery of BACE1 siRNA loaded in solid lipid nanoparticles for Alzheimer’s therapy
Rassu, Giovanna; Soddu, Elena; Posadino, Anna Maria; Pintus, Gianfranco; Sarmento, Bruno; Giunchedi, Paolo; Gavini, Elisabetta... more authors ... less authors ( Elsevier , 2017 , Article)Abstract We designed a delivery system to obtain an efficient and optimal nose-to-brain transport of BACE1 siRNA, potentially useful in the treatment of Alzheimer's disease. We selected a cell-penetrating peptide, the short ... -
Oxidative stress-induced Akt downregulation mediates green tea toxicity towards prostate cancer cells
Posadino, Anna Maria; Phu, Hoa Thi; Cossu, Annalisa; Giordo, Roberta; Fois, Marco; Thuan, Duong Thi Bich; Piga, Antonio; Sotgia, Salvatore; Zinellu, Angelo; Carru, Ciriaco; Pintus, Gianfranco... more authors ... less authors ( Elsevier , 2017 , Article)Green tea consumption has been shown to possess cancer chemopreventive activity. Polyphenol E (PE) is a widely used standardized green tea extract formulation. This study was designed to investigate the impact of PE on ... -
Potential Adverse Effects of Resveratrol: A Literature Review.
Shaito, Abdullah; Posadino, Anna Maria; Younes, Nadin; Hasan, Hiba; Halabi, Sarah; Alhababi, Dalal; Al-Mohannadi, Anjud; Abdel-Rahman, Wael M; Eid, Ali H; Nasrallah, Gheyath K; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2020 , Article Review)Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive ... -
Protective Effect of Cyclically Pressurized Solid⁻Liquid Extraction Polyphenols from Grape Pomace on Oxidative Endothelial Cell Death.
Posadino, Anna Maria; Biosa, Grazia; Zayed, Hatem; Abou-Saleh, Haissam; Cossu, Annalisa; Nasrallah, Gheyath K; Giordo, Roberta; Pagnozzi, Daniela; Porcu, Maria Cristina; Pretti, Luca; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2018 , Article)The aim of this work is the evaluation of a green extraction technology to exploit winery waste byproducts. Specifically, a solid⁻liquid extraction technology (Naviglio Extractor) was used to obtain polyphenolic antioxidants ... -
Resveratrol-Elicited PKC Inhibition Counteracts NOX-Mediated Endothelial to Mesenchymal Transition in Human Retinal Endothelial Cells Exposed to High Glucose
Giordo, Roberta; Nasrallah, Gheyath K.; Posadino, Anna Maria; Galimi, Francesco; Capobianco, Giampiero; Eid, Ali Hussein; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2021 , Article)Diabetes-associated long-term hyperglycaemia leads to oxidative stress-mediated fibrosis in different tissues and organs. Endothelial-to-mesenchymal-transition (EndMT) appears to play a role in diabetes-associated fibrotic ... -
Resveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: molecular insights and potential therapeutic applications.
Shaito, Abdullah; Al-Mansoob, Maryam; Ahmad, Salma M S; Haider, Mohammad Z; Eid, Ali H; Posadino, Anna Maria; Pintus, Gianfranco; Giordo, Roberta... more authors ... less authors ( Bentham Science Publisher , 2022 , Article Review)Neurodegenerative disorders include neurological conditions that affect nerve cells, causing the progressive loss of their functions and ultimately leading to loss of mobility, coordination, and mental functioning. The ...