تصفح حسب المؤلف "Malek, Joel A."
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Assessment of the Risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reinfection in an Intense Reexposure Setting
Abu-Raddad, Laith J.; Chemaitelly, Hiam; Malek, Joel A.; Ahmed, Ayeda A.; Mohamoud, Yasmin A.; Younuskunju, Shameem; Ayoub, Houssein H.; Al Kanaani, Zaina; Al Khal, Abdullatif; Al Kuwari, Einas; Butt, Adeel A.; Coyle, Peter; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul Rahim, Hanan F.; Yassine, Hadi M.; Al Kuwari, Mohamed G.; Al Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Bertollini, Roberto... more authors ... less authors ( NLM (Medline) , 2021 , Article)BACKGROUND: Risk of reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. We assessed the risk and incidence rate of documented SARS-CoV-2 reinfection in a cohort of laboratory-confirmed ... -
Discovery of new therapeutic targets in ovarian cancer through identifying significantly non-mutated genes
Al-Farsi, Halema; Al-Azwani, Iman; Malek, Joel A.; Chouchane, Lotfi; Rafii, Arash; Halabi, Najeeb M.... more authors ... less authors ( BioMed Central Ltd , 2022 , Article)Background: Mutated and non-mutated genes interact to drive cancer growth and metastasis. While research has focused on understanding the impact of mutated genes on cancer biology, understanding non-mutated genes that are ... -
mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar
Chemaitelly, Hiam; Yassine, Hadi M.; Benslimane, Fatiha M.; Al Khatib, Hebah A.; Tang, Patrick; Hasan, Mohammad R.; Malek, Joel A.; Coyle, Peter; Ayoub, Houssein H.; Al Kanaani, Zaina; Al Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul Rahim, Hanan F.; Nasrallah, Gheyath K.; Al Kuwari, Mohamed Ghaith; Al Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Al Khal, Abdullatif; Butt, Adeel A.; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors (2021 , Article)The SARS-CoV-2 pandemic continues to be a global health concern. The mRNA-1273 (Moderna) vaccine was reported to have an efficacy of 94.1% at preventing symptomatic COVID-19 due to infection with ‘wild-type’ variants in a ... -
One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar
Benslimane, Fatiha M; Al Khatib, Hebah A; Al-Jamal, Ola; Albatesh, Dana; Boughattas, Sonia; Ahmed, Ayeda A; Bensaad, Meryem; Younuskunju, Shameem; Mohamoud, Yasmin A; Al Badr, Mashael; Mohamed, Abdalla A; El-Kahlout, Reham A; Al-Hamad, Tasneem; Elgakhlab, Dina; Al-Kuwari, Fatima H; Saad, Chadi; Jeremijenko, Andrew; Al-Khal, Abdullatif; Al-Maslamani, Muna A; Bertollini, Roberto; Al-Kuwari, Einas A; Al-Romaihi, Hamad E; Al-Marri, Salih; Al-Thani, Mohammed; Badji, Radja M; Mbarek, Hamdi; Al-Sarraj, Yasser; Malek, Joel A; Ismail, Said I; Abu-Raddad, Laith J; Coyle, Peter V; Thani, Asmaa A Al; Yassine, Hadi M... more authors ... less authors ( Frontiers , 2021 , Article)Qatar, a country with a strong health system and a diverse population consisting mainly of expatriate residents, has experienced two large waves of COVID-19 outbreak. In this study, we report on 2634 SARS-CoV-2 whole-genome ... -
Pfizer-BioNTech mRNA BNT162b2 Covid-19 vaccine protection against variants of concern after one versus two doses.
Abu-Raddad, Laith J; Chemaitelly, Hiam; Yassine, Hadi M; Benslimane, Fatiha M; Al Khatib, Hebah A; Tang, Patrick; Malek, Joel A; Coyle, Peter; Ayoub, Houssein H; Al Kanaani, Zaina; Al Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul Rahim, Hanan F; Nasrallah, Gheyath K; Al Kuwari, Mohamed Ghaith; Al Romaihi, Hamad Eid; Al-Thani, Mohamed H; Al Khal, Abdullatif; Butt, Adeel A; Bertollini, Roberto... more authors ... less authors ( Oxford University Press , 2021 , Article)Strategies for rolling out vaccination against Coronavirus Disease 2019 (Covid-19) varied across countries. A key question is whether delaying administration of the second vaccine dose to vaccinate the largest number of ... -
SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy
Laith J., Abu-Raddad; Chemaitelly, Hiam; Coyle, Peter; Malek, Joel A.; Ahmed, Ayeda A.; Mohamoud, Yasmin A.; Younuskunju, Shameem; Ayoub, Houssein H.; Al Kanaani, Zaina; Al Kuwari, Einas; Butt, Adeel A.; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul Rahim, Hanan F.; Nasrallah, Gheyath K.; Yassine, Hadi M.; Al Kuwari, Mohamed Ghaith; Al Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Al Khal, Abdullatif; Bertollini, Roberto... more authors ... less authors ( Elsevier , 2021 , Article)Background Reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been documented, raising public health concerns. SARS-CoV-2 reinfections were assessed in a cohort of antibody-positive persons ... -
The QChip1 knowledgebase and microarray for precision medicine in Qatar
Rodriguez-Flores, Juan L.; Messai-Badji, Radja; Robay, Amal; Temanni, Ramzi; Syed, Najeeb; Markovic, Monika; Al-khayat, Eiman; Qafoud, Fatima; Nawaz, Zafar; Badii, Ramin; Al-Sarraj, Yasser; Mbarek, Hamdi; Al-Muftah, Wadha; Alvi, Muhammad; Rostami, Mahboubeh R.; Cruzado, Juan Carlos Martinez; Mezey, Jason G.; Shakaki, Alya Al; Malek, Joel A.; Greenblatt, Matthew B.; Fakhro, Khalid A.; Machaca, Khaled; Al-Nabet, Ajayeb; Afifi, Nahla; Brooks, Andrew; Ismail, Said I.; Althani, Asmaa; Crystal, Ronald G.... more authors ... less authors ( Nature Research , 2022 , Article)Risk genes for Mendelian (single-gene) disorders (SGDs) are consistent across populations, but pathogenic risk variants that cause SGDs are typically population-private. The goal was to develop "QChip1," an inexpensive ... -
Two prolonged viremic SARS-CoV-2 infections with conserved viral genome for two months
Laith J., Abu-Raddad; Chemaitelly, Hiam; Malek, Joel A.; Ahmed, Ayeda A.; Mohamoud, Yasmin A.; Younuskunju, Shameem; Al Kanaani, Zaina; Al Khal, Abdullatif; Al Kuwari, Einas; Butt, Adeel A.; Coyle, Peter; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul Rahim, Hanan F.; Yassine, Hadi M.; Al Kuwari, Mohamed G.; Al Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Bertollini, Roberto... more authors ... less authors ( Elsevier , 2021 , Article)We document two cases of viremic and prolonged active infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where the viral genome was conserved for two months, but infection was with little or ...