Browsing by Author "Steinhoff M."
Now showing items 1-9 of 9
-
Clinical presentation, management, and pathophysiology of neuropathic itch
Steinhoff M.; Schmelz M.; Szab? I.L.; Oaklander A.L. ( Lancet Publishing Group , 2018 , Article Review)Unlike conventional itch, neuropathic itch develops in normal skin from excess peripheral firing or dampened central inhibition of itch pathway neurons. Neuropathic itch is a symptom of the same central and peripheral ... -
Greensporone A, a fungal secondary metabolite suppressed constitutively activated AKT via ROS generation and induced apoptosis in leukemic cell lines
Prabhu K.S.; Siveen K.S.; Kuttikrishnan S.; Jochebeth A.; Ali T.A.; Elareer N.R.; Iskandarani A.; Khan A.Q.; Merhi M.; Dermime S.; El-Elimat T.; Oberlies N.H.; Alali F.Q.; Steinhoff M.; Uddin S.... more authors ... less authors ( MDPI AG , 2019 , Article)Greensporone A is a fungal secondary metabolite that has exhibited potential in vitro for anti-proliferative activity in vitro. We studied the anticancer activity of greensporone A in a panel of leukemic cell lines. ... -
Interleukin-4 and interleukin-13 evoke scratching behaviour in mice
Campion M.; Smith L.; Gatault S.; Métais C.; Buddenkotte J.; Steinhoff M.... more authors ... less authors ( Blackwell Publishing Ltd , 2019 , Article)Persistent and relapsing itch commonly manifests in inflammatory skin disorders such as atopic dermatitis (AD). AD pathogenesis is driven by interleukin-4 (IL-4) and interleukin-13 (IL-13). Dupilumab, a monoclonal antibody ... -
Lichen planus: a comprehensive evidence-based analysis of medical treatment
Husein-ElAhmed H.; Gieler U.; Steinhoff M. ( Blackwell Publishing Ltd , 2019 , Article Review)Lichen planus (LP) is a chronic-relapsing inflammatory skin disease. Although many drugs have been used for the management of LP, some of them lack the backup by strong therapeutic evidence, while others are not suitable ... -
Neuropathic itch
Steinhoff M.; Oaklander A.L.; Szab I.L.; Stnder S.; Schmelz M. ( NLM (Medline) , 2019 , Article)Neuropathic itch is clinically important but has received much less attention as compared to neuropathic pain. In the past decade, itch-specific pathways have been characterized on a cellular and molecular level, but their ... -
Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis
Manresa M.C.; Smith L.; Casals-Diaz L.; Fagundes R.R.; Brown E.; Radhakrishnan P.; Murphy S.J.; Crifo B.; Strowitzki M.J.; Halligan D.N.; van den Bogaard E.H.; Niehues H.; Schneider M.; Taylor C.T.; Steinhoff M.... more authors ... less authors ( Blackwell Publishing Ltd , 2019 , Article)Background When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular hypoxia. The hypoxia‐inducible ... -
Protein expression profiling identifies key proteins and pathways involved in growth inhibitory effects exerted by guggulsterone in human colorectal cancer cells
Leo R.; Therachiyil L.; Siveen S.K.; Uddin S.; Kulinski M.; Buddenkotte J.; Steinhoff M.; Krishnankutty R.... more authors ... less authors ( MDPI AG , 2019 , Article)Colorectal cancer (CRC) is a leading killer cancer worldwide and one of the most common malignancies with increasing incidences of mortality. Guggulsterone (GS) is a plant sterol used for treatment of various ailments such ... -
Role of mast cells and basophils in pruritus
Steinhoff M.; Buddenkotte J.; Lerner E.A. ( Blackwell Publishing Ltd , 2018 , Article Review)To protect our body systems, there is a constant interactive conversation between the skin nervous and immune system. Important elements of this conversation in the skin include mast cells, basophils, and sensory nerve ... -
Understanding the Burden of Atopic Dermatitis in Africa and the Middle East
Al-Afif K.A.M.; Buraik M.A.; Buddenkotte J.; Mounir M.; Gerber R.; Ahmed H.M.; Tallman A.M.; Steinhoff M.... more authors ... less authors ( Springer Healthcare , 2019 , Article Review)Atopic dermatitis (AD) is a common inflammatory skin disease characterized by intensely pruritic lesions. The prevalence of atopic dermatitis is increasing in developing regions, including Africa and the Middle East. ...