تصفح حسب الموضوع "enzyme inhibition"
السجلات المعروضة 1 -- 3 من 3
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A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin
( Taylor and Francis Ltd. , 2021 , Article)The widespread antigenic changes lead to the emergence of a new type of coronavirus (CoV) called as severe acute respiratory syndrome (SARS)-CoV-2 that is immunologically different from the previous circulating species. ... -
Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors
( Elsevier Masson SAS , 2016 , Article)A novel series of substituted chalcones were designed and synthesized to be evaluated as selective human MAO-B inhibitors. A combination of either methylsulfonyl or trifluoromethyl substituents on the aromatic ketone moiety ... -
Effect of hyperlipidemia on ketoconazole-midazolam drug-drug interaction in rat
( John Wiley & Sons, Ltd. , 2011 , Article)Hyperlipidemia (HL) was previously shown to lower liver uptake of the more potent (-) enantiomer of ketoconazole (KTZ) in rat. The current study examined the possible modifying influence of experimental HL on a KTZ ...