Browsing Academic by Author "S., Udhaya Kumar"
Now showing items 1-7 of 7
-
Comparison of potential inhibitors and targeting fat mass and obesity-associated protein causing diabesity through docking and molecular dynamics strategies.
S, Udhaya Kumar; Rajan, Bithia; D, Thirumal Kumar; R, Hephzibah Cathryn; V, Samprita Das.; Zayed, Hatem; Walter, Charles Emmanuel Jebaraj; Ramanathan, Gnanasambandan; Doss, George Priya... more authors ... less authors ( Wiley , 2021 , Article)Genome-wide association studies (GWAS) have identified an association between polymorphisms in the FTO gene and obesity. The FTO: rs9939609, an intronic variant, is considered a risk allele for developing diabesity in ... -
A computational overview on phylogenetic characterization, pathogenic mutations, and drug targets for Ebola virus disease
Vasudevan, Karthick; D, Thirumal Kumar; S, Udhaya Kumar; Saleem, Aisha; N, Nagasundaram; R, Siva; Tayubi, Iftikhar Aslam; Doss, C. George Priya; Zayed, Hatem... more authors ... less authors ( Elsevier , 2021 , Article)The World Health Organization declared Ebola virus disease(EVD) as the major outbreak in the 20th century. EVD was firstidentified in 1976 in South Sudan and the Democratic Republicof the Congo. EVD was transmitted from ... -
Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach.
S, Udhaya Kumar; Sankar, Srivarshini; Younes, Salma; D, Thirumal Kumar; Ahmad, Muneera Naseer; Okashah, Sarah Samer; Kamaraj, Balu; Al-Subaie, Abeer Mohammed; C, George Priya Doss; Zayed, Hatem... more authors ... less authors ( MDPI , 2020 , Article)Filamins (FLN) are a family of actin-binding proteins involved in regulating the cytoskeleton and signaling phenomenon by developing a network with F-actin and FLN-binding partners. The FLN family comprises three conserved ... -
An extensive computational approach to analyze and characterize the functional mutations in the galactose-1-phosphate uridyl transferase (GALT) protein responsible for classical galactosemia
S, Udhaya Kumar; D, Thirumal Kumar; R, Siva; C, George Priya Doss; Zayed, Hatem ( Elsevier , 2019 , Article)Type I galactosemia is a very rare autosomal recessive genetic metabolic disorder that occurs because of the mutations present in the galactose-1-phosphate uridyl transferase (GALT) gene, resulting in a deficiency of the ... -
Identification of potential inhibitors against pathogenic missense mutations of PMM2 using a structure-based virtual screening approach.
Thirumal Kumar, D; Jain, Nikita; S, Udhaya Kumar; GeorgePriya Doss, C; Zayed, Hatem ( Taylor & Francis , 2019 , Article)The autosomal recessive phosphomannomutase 2-congenital disorder of glycosylation (PMM2-CDG) is characterized by defective functioning of the PMM2 enzyme, which is necessary for the conversion of mannose-6-phosphate into ... -
Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity
S, Udhaya Kumar; Rajan, Bithia; D, Thirumal Kumar; V, Anu Preethi; Abunada, Taghreed; Younes, Salma; Okashah, Sarah; Ethiraj, Selvarajan; C, George Priya Doss; Zayed, Hatem... more authors ... less authors ( MDPI , 2020 , Article)(1) Aims: Diabesity, defined as diabetes occurring in the context of obesity, is a serious health problem that is associated with an increased risk of premature heart attack, stroke, and death. To date, a key challenge has ... -
Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach
S, Udhaya Kumar; R, Bithia; D, Thirumal Kumar; Doss, C George Priya; Zayed, Hatem ( Taylor and Francis , 2020 , Article)K-Ras is a small GTPase and acts as a molecular switch by recruiting GEFs and GAPs, and alternates between the inert GDP-bound and the dynamic GTP-bound forms. The amino acid at position 12 of K-Ras is a hot spot for ...