تصفح Academic حسب المؤلف "Vaikath, Nishant N."
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Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity
Gupta, Vijay; Salim, Safa; Hmila, Issam; Vaikath, Nishant N.; Sudhakaran, Indulekha P.; Ghanem, Simona S.; Majbour, Nour K.; Abdulla, Sara A.; Emara, Mohamed M.; Abdesselem, Houari B.; Lukacsovich, Tamas; Erskine, Daniel; El-Agnaf, Omar M.A.... more authors ... less authors ( Springer Nature , 2020 , Article)Synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are characterized by pathological accumulation of α-synuclein (α-syn). Amongst the various approaches ... -
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
Ardah, Mustafa T; Ghanem, Simona S; Abdulla, Sara A; Lv, Guohua; Emara, Mohamed M; Paleologou, Katerina E; Vaikath, Nishant N; Lu, Jia-Hong; Li, Min; Vekrellis, Konstantinos; Eliezer, David; El-Agnaf, Omar M A... more authors ... less authors ( BMC , 2020 , Article)Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson's disease (PD), multiple system atrophy, and dementia ... -
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.
Hmila, Issam; Vaikath, Nishant N; Majbour, Nour K; Erskine, Daniel; Sudhakaran, Indulekha P; Gupta, Vijay; Ghanem, Simona S; Islam, Zeyaul; Emara, Mohamed M; Abdesselem, Houari B; Kolatkar, Prasanna R; Achappa, Devaya K; Vinardell, Tatiana; El-Agnaf, Omar M A... more authors ... less authors ( FEBS PRESS , 2022 , Article)Nanobodies (Nbs), the single-domain antigen-binding fragments of dromedary heavy-chain antibodies (HCAb), are excellent candidates as therapeutic and diagnostic tools in synucleinopathies because of their small size, ... -
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
Majbour, Nour K.; Vaikath, Nishant N.; van Dijk, Karin D.; Ardah, Mustafa T.; Varghese, Shiji; Vesterager, Louise B.; Montezinho, Liliana P.; Poole, Stephen; Safieh-Garabedian, Bared; Tokuda, Takahiko; Teunissen, Charlotte E.; Berendse, Henk W.; van de Berg, Wilma D. J.; El-Agnaf, Omar M. A.... more authors ... less authors ( BioMed Central , 2016 , Article)Background Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson’s disease (PD) based on biochemical analysis of blood or CSF. However, neurodegeneration in the brains of PD patients ...