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Efficacy and safety of selinexor for patients with relapsed and refractory multiple myeloma: A meta-analysis
(
Elsevier
, 2024 , Article)
PurposeSelinexor is a first-in-class, oral selective-inhibitor-of-nuclear-export, granted accelerated approval by FDA (2019) for relapsed and refractory multiple myeloma (RRMM). We sought to quantitatively summarize the ...
Efficacy and Clinical Outcomes of mRNA COVID-19 Vaccine in Pregnancy: A Systematic Review and Meta-Analysis
(
S. Karger AG
, 2024 , Article)
BACKGROUND: The world has witnessed one of the largest pandemics, dubbed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of December 2020, the USA alone reported 98,948 cases of coronavirus disease 2019 ...
Reproductive functions of progesterone
(
Middle East Fertility Society
, 2007 , Other)
Progesterone has a central role in reproduction, being involved in ovulation, implantation, and pregnancy. Associated with this is the involvement of progesterone in regulation of uterine function during the menstrual ...
Bi-attention DoubleUNet: A deep learning approach for carotid artery segmentation in transverse view images for non-invasive stenosis diagnosis
(
Elsevier
, 2024 , Article)
The carotid artery is a vital blood vessel that supplies oxygenated blood to the brain. Blockages in this artery can lead to life-threatening illnesses, making accurate diagnosis essential. While ultrasound (US) imaging ...
Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria
(
Portland Press Ltd
, 2024 , Article)
Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a deficiency of cystathionine β-synthase (CBS). CBS is an essential pyridoxal 50-phosphate (PLP)-dependent enzyme in the transsulfuration ...
Circadian Syndrome Is Associated with Dietary Patterns among Middle-Older Americans: The Health and Retirement Study
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2024 , Article)
Population aging is a global demographic characteristic of the 21st century, and healthy eating is a core component of healthy aging. However, limited evidence is available among older adults for associations between diet ...
Effectiveness of locally produced ready-to-use supplementary foods on the prevention of stunting in children aged 6-23 months: A community-based trial from Pakistan
(
Cambridge University Press
, 2023 , Article)
Undernutrition is a major public health problem in developing countries. Around 40·2 % of children are stunted in Pakistan. This longitudinal study aimed to assess the effectiveness of locally produced ready-to-use ...
BRCA1 and Its Vulnerable C-Terminal BRCT Domain: Structure, Function, Genetic Mutations and Links to Diagnosis and Treatment of Breast and Ovarian Cancer
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2024 , Article)
The BRCA1 is a tumor suppressor gene that encodes for the BRCA1 protein, which plays a vital role in DNA repair, cell cycle regulation, and the maintenance of genomic stability. The BRCA1 protein interacts with a variety ...
Exploring the role of oral microbiome dysbiosis in cardiometabolic syndrome and smoking
(
Taylor and Francis Ltd.
, 2024 , Article Review)
Oral microbiome research has gained significant interest in recent years due to its potential impact on overall health. Smoking has been identified as a significant modulator of the oral microbiome composition, leading to ...
Nrf-2-dependent antioxidant and anti-inflammatory effects underlie the protective effect of esculeoside A against retinal damage in streptozotocin-induced diabetic rats
(
Elsevier
, 2024 , Article)
Esculeoside A (ESA) is a tomato-derived glycoside with antioxidant and anti-inflammatory properties. The protective effect of ESA against diabetic retinopathy is not well-investigated and was the core objective of this ...