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المؤلفChivese, Tawanda
المؤلفMatizanadzo, Joshua T
المؤلفMusa, Omran A H
المؤلفHindy, George
المؤلفFuruya-Kanamori, Luis
المؤلفIslam, Nazmul
المؤلفAl-Shebly, Rafal
المؤلفShalaby, Rana
المؤلفHabibullah, Mohammad
المؤلفAl-Marwani, Talal A
المؤلفHourani, Rizeq F
المؤلفNawaz, Ahmed D
المؤلفHaider, Mohammad Z
المؤلفEmara, Mohamed M
المؤلفCyprian, Farhan
المؤلفDoi, Suhail A R
تاريخ الإتاحة2022-02-14T09:19:41Z
تاريخ النشر2022-01-31
اسم المنشورPathogens and Global Health
المعرّفhttp://dx.doi.org/10.1080/20477724.2022.2029301
الاقتباسTawanda Chivese, Joshua T. Matizanadzo, Omran A. H. Musa, George Hindy, Luis Furuya-Kanamori, Nazmul Islam, Rafal Al-Shebly, Rana Shalaby, Mohammad Habibullah, Talal A. Al-Marwani, Rizeq F. Hourani, Ahmed D. Nawaz, Mohammad Z. Haider, Mohamed M. Emara, Farhan Cyprian & Suhail A. R. Doi (2022): The prevalence of adaptive immunity to COVID-19 and reinfection after recovery – a comprehensive systematic review and meta-analysis, Pathogens and Global Health, DOI: 10.1080/20477724.2022.2029301
معرّف المصادر الموحدhttp://hdl.handle.net/10576/26898
الملخصThis study aims to estimate the prevalence and longevity of detectable SARS-CoV-2 antibodies and T and B memory cells after recovery. In addition, the prevalence of COVID-19 reinfection and the preventive efficacy of previous infection with SARS-CoV-2 were investigated. A synthesis of existing research was conducted. The Cochrane Library, the China Academic Journals Full Text Database, PubMed, and Scopus, and preprint servers were searched for studies conducted between 1 January 2020 to 1 April 2021. Included studies were assessed for methodological quality and pooled estimates of relevant outcomes were obtained in a meta-analysis using a bias adjusted synthesis method. Proportions were synthesized with the Freeman-Tukey double arcsine transformation and binary outcomes using the odds ratio (OR). Heterogeneity was assessed using the I and Cochran's Q statistics and publication bias was assessed using Doi plots. Fifty-four studies from 18 countries, with around 12,000,000 individuals, followed up to 8 months after recovery, were included. At 6-8 months after recovery, the prevalence of SARS-CoV-2 specific immunological memory remained high; IgG - 90.4% (95%CI 72.2-99.9, I = 89.0%), CD4+ - 91.7% (95%CI 78.2-97.1y), and memory B cells 80.6% (95%CI 65.0-90.2) and the pooled prevalence of reinfection was 0.2% (95%CI 0.0-0.7, I = 98.8). Individuals previously infected with SARS-CoV-2 had an 81% reduction in odds of a reinfection (OR 0.19, 95% CI 0.1-0.3, I = 90.5%). Around 90% of recovered individuals had evidence of immunological memory to SARS-CoV-2, at 6-8 months after recovery and had a low risk of reinfection.
اللغةen
الناشرTaylor & Francis
العلاقةhttps://doi.org/10.29117/quarfe.2021.0146
الموضوعCOVID-19
SARS-CoV-2
adaptive immunity
antibodies
preventive efficacy
reinfection
العنوانThe prevalence of adaptive immunity to COVID-19 and reinfection after recovery - a comprehensive systematic review and meta-analysis.
النوعArticle


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