Browsing Biomedical Sciences by Author "Wan Taib, Wan Rohani"
Now showing items 1-2 of 2
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Gene Expression Profiling and Protein Analysis Reveal Suppression of the C-Myc Oncogene and Inhibition JAK/STAT and PI3K/AKT/mTOR Signaling by Thymoquinone in Acute Myeloid Leukemia Cells
Almajali, Belal; Johan, Muhammad Farid; Al-Wajeeh, Abdullah Saleh; Wan Taib, Wan Rohani; Ismail, Imilia; Alhawamdeh, Maysa; Al-Tawarah, Nafe M.; Ibrahim, Wisam Nabeel; Al-Rawashde, Futoon Abedrabbu; Al-Jamal, Hamid Ali Nagi... more authors ... less authors ( MDPI , 2022 , Article)Overexpression of c-Myc plays an essential role in leukemogenesis and drug resistance, making c-Myc an attractive target for cancer therapy. However, targeting c-Myc directly is impossible, and c-Myc upstream regulator ... -
Thymoquinone Suppresses Cell Proliferation and Enhances Apoptosis of HL60 Leukemia Cells through Re-Expression of JAK/STAT Negative Regulators.
Almajali, Belal; Al-Jamal, Hamid Ali Nagi; Wan Taib, Wan Rohani; Ismail, Imilia; Johan, Muhammad Farid; Doolaanea, Abd Almonem; Ibrahim, Wisam Nabeel; Tajudin, Syed Ahmad... more authors ... less authors ( West Asia Organization for Cancer Prevention (WAOCP) , 2021 , Article)The natural compound, thymoquinone (TQ) has demonstrated potential anticancer properties in inhibiting cell proliferation and promoting apoptosis in myeloid leukemia cells, breast cancer cells, and others. However, the ...