Browsing Biomedical Sciences by Author "Malki, Ahmed"
Now showing items 1-9 of 9
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Antitumor Activities of the Novel Isosteviol Derivative 10C Against Liver Cancer
Malki, Ahmed; El-Sharkawy, Ahmed; El Syaed, Mohamed; Bergmeier, Stephen ( International Institute of Anticancer Research , 2017 , Article)Background/Aim. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the fifth most common primary malignancy with worldwide increasing incidence. The current study aims to investigate the anticancer ... -
Association between metabolically healthy obesity and metastasis in lung cancer patients – a systematic review and meta-analysis
Malki, Ahmed; Shaik, Riyaz Ahamed; Sami, Waqas ( Frontiers Media , 2023 , Article Review)Background: Many clinical trials have looked at the relationship between obesity and lung cancer (LC), however, there is scarcity of literature specifically addressing the association between metabolically healthy obesity ... -
E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis.
Ashour, Anas; Alhussain, Hashim; Rashid, Umar Bin; Abughazzah, Labiba; Gupta, Ishita; Malki, Ahmed; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI , 2020 , Article)E-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a "healthy method" of tobacco consumption. The adverse outcomes of ECS on the respiratory and cardiovascular ... -
In vitro and in vivo efficacy of a novel quinuclidinone derivative against breast cancer
Malki, A.; Malki, Ahmed; El Ashry, El Sayed ( International Institute of Anticancer Research , 2014 , Other)Previously, our laboratory reported on novel quinuclidinone derivatives that cause cytotoxicity in human non-small lung carcinoma epithelial cells null for p53 (H1299). The current study aims to investigate the effect of ... -
Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements.
malki, ahmed; ElRuz, Rasha; Gupta, I.; Allouch, A; vranic, S; Al moustafa, A E... more authors ... less authors ( MDPI , 2020 , Article Review)Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause of cancer-related mortality rates worldwide. Although modern research was able to shed light on the pathogenesis of CRC and provide ... -
Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells
Malki, Ahmed; Ashour, Hayam M. A.; Elbayaa, Rasha Y.; Issa, Doaa A. E.; Aziz, Hassan A.; Chen, Xiaozhuo... more authors ... less authors ( Taylor and Francis Ltd , 2016 , Article)Novel 1,5-diphenyl-6-substituted-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones were synthesized and characterized. All compounds were screened for their anti-proliferative activities in five different cancer cell lines. The results ... -
Novel Isosteviol Derivatives Induced Apoptosis In Human Lung Cancer
Malki, Ahmed; Bergmeier, Stephen ( Hamad bin Khalifa University Press (HBKU Press) , 2014 , Conference Paper)Background. Cancer metastasis is the major cause of cancer death. We previously reported novel isosteviols derivatives which induced cytotoxicity in lung cancer cells. The understanding of mechanisms which regulate lung ... -
Novel Quinuclidinone Derivatives Induced Apoptosis in Human Breast Cancer via Targeting P53
Malki, Ahmed; Elbayaa, Rasha Y.; Ali, Omnia; Sultan, Ahmed; Youssef, Amal M. ( Elsevier , 2017 , Article)Small molecules that can target human cancers have been highly sought to increase the anticancer efficacy, the present work describes the design and synthesis of novel series of five quinuclidinone derivatives (2a-2e). ... -
Vitamin D Signaling in Inflammation and Cancer: Molecular Mechanisms and Therapeutic Implications
El-Sharkawy, Ahmed; Malki, Ahmed ( MDPI , 2020 , Article Review)Vitamin D and its active metabolites are important nutrients for human skeletal health. UV irradiation of skin converts 7-dehydrocholesterol into vitamin D3, which metabolized in the liver and kidneys into its active form, ...