Browsing by Author "Djouhri, Laiche"
Now showing items 1-14 of 14
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Activation of K7 channels with the anticonvulsant retigabine alleviates neuropathic pain behaviour in the streptozotocin rat model of diabetic neuropathy.
Djouhri, Laiche; Malki, MohammedImad; Zeidan, Asad; Nagi, Karim; Smith, Trevor ( Taylor & Francis (Routledge) , 2019 , Article)Diabetic peripheral neuropathy (DPN) is the most incapacitating complication of diabetes mellitus. Up to 50% of patients with DPN develop peripheral neuropathic pain (PNP). The underlying ionic and molecular mechanisms of ... -
Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study
Alsuwaidi, Hissa N.; Ahmed, Ashraf I.; Alkorbi, Hamad A.; Ali, Sara M.; Altarawneh, Lina N.; Uddin, Shooq I.; Roueentan, Sara R.; Alhitmi, Asmaa A.; Djouhri, Laiche; Chivese, Tawanda... more authors ... less authors ( Dave Medical Press Limited, , 2023 , Article)Aim: We investigated whether metabolic syndrome (MetS) is associated with a decline in cognitive function in a cohort of middle-aged and elderly individuals without known cognitive dysfunction diseases in Qatar. Methods: ... -
Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling
Kamareddine, Layla; Ghantous, Crystal; Allouch, Soumaya; Al-Ashmar, Sara; Anlar, Gulsen; Kannan, Surya; Djouhri, Laiche; Korashy, Hesham; Agouni, Abdelali; Zeidan, Asad... more authors ... less authors ( Dove Medical Press , 2021 , Article Review)Cardiac remodeling is the process by which the heart adapts to stressful stimuli, such as hypertension and ischemia/reperfusion; it ultimately leads to heart failure upon long- term exposure. Autophagy, a cellular catabolic ... -
Cutaneous Aβ-Non-nociceptive, but Not C-Nociceptive, Dorsal Root Ganglion Neurons Exhibit Spontaneous Activity in the Streptozotocin Rat Model of Painful Diabetic Neuropathy .
Djouhri, Laiche; Zeidan, Asad; Abd El-Aleem, Seham A; Smith, Trevor ( Frontiers Media , 2020 , Article)Diabetic peripheral neuropathic pain (DPNP) is the most devastating complication of diabetes mellitus. Unfortunately, successful therapy for DPNP remains a challenge because its pathogenesis is still elusive. However, DPNP ... -
Follicular dendritic cells
Abd El-Aleem, Seham A; Saber, Entesar Ali; Aziz, Neven M; El-Sherif, Hani; Abdelraof, Asmaa M; Djouhri, Laiche... more authors ... less authors ( Wiley , 2021 , Article Review)Follicular dendritic cells (FDCs) are unique accessory immune cells that contribute to the regulation of humoral immunity. They are multitasker cells essential for the organization and maintenance of the lymphoid architecture, ... -
A Golgi study of neurons in the camel cerebellum (Camelus dromedarius)
Al-Hussain, Saleh M.; Yousuf, Mustafa S.; Hani, Ayat Bani; Zaqout, Sami; Djouhri, Laiche; Mustafa, Ayman G.... more authors ... less authors ( Wiley , 2021 , Article)Neurons in the cerebellar cortex of camels were studied using modified Golgi impregnation methods. Neurons were classified according to their position, morphology of their soma, density and distribution of dendrites, and ... -
Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders
Abdelsam, Shahenda Salah; Ghanem, Sarah Khalaf; Zahid, Muhammad Ammar; Abunada, Hanan H.; Bader, Loulia; Raïq, Hicham; Khan, Abbas; Parray, Aijaz; Djouhri, Laiche; Agouni, Abdelali... more authors ... less authors ( Wiley , 2024 , Article Review)RNA-binding proteins (RBPs) play a crucial role in the regulation of posttranscriptional RNA networks, which can undergo dysregulation in many pathological conditions. Human antigen R (HuR) is a highly researched RBP that ... -
Involvement of caveolae in hyperglycemia-induced changes in adiponectin and leptin expressions in vascular smooth muscle cells
Ola, El Atab; Ghantous, Crystal M.; El-Zein, Nabil; Farhat, Rima; Agouni, Abdelali; Korashy, Hesham M.; Djouhri, Laiche; Kamareddine, Layla; Zibara, Kazem; Zeidan, Asad... more authors ... less authors ( Elsevier , 2021 , Article)Hyperglycemia exerts various harmful effects on the vasculature. Studies have shown an association between the levels of the adipokines leptin and adiponectin (APN) and vascular complications in diabetes mellitus. The aim ... -
L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats .
Djouhri, Laiche; Zeidan, Asad; Alzoghaibi, Mohammad; Al Otaibi, Mohammad F; Abd El-Aleem, Seham A ( Mary Ann Liebert , 2020 , Article)Peripheral neuropathic pain (PNP) is a major health problem for which effective drug treatment is lacking. Its underlying neuronal mechanisms are still illusive, but pre-clinical studies using animal models of PNP including ... -
Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
Ghantous, Crystal M.; Farhat, Rima; Djouhri, Laiche; Alashmar, Sarah; Anlar, Gulsen; Korashy, Hesham M.; Agouni, Abdelali; Zeidan, Asad... more authors ... less authors ( hindawi , 2020 , Article)Hypertension induces vascular hypertrophy, which changes blood vessels structurally and functionally, leading to reduced tissue perfusion and further hypertension. It is also associated with dysregulated levels of the ... -
Mutual inter-regulation between iNOS and TGF-β1: Possible molecular and cellular mechanisms of iNOS in wound healing.
Abd El-Aleem, Seham A; Mohammed, Hanaa Hassanein; Saber, Entesar Ali; Embaby, Azza S; Djouhri, Laiche ( Elsevier , 2020 , Article)Abnormal wound healing with excessive scarring is a major health problem with socioeconomic and psychological impacts. In human, chronic wounds and scarring are associated with upregulation of the inducible nitric oxide ... -
Neuronal Cell Types in the Spinal Trigeminal Nucleus of the Camel Brain.
El-Dwairi, Qasim A; Al-Hussain, Saleh M; Banihani, Ayat S; Bataineh, Ziad M; Djouhri, Laiche; Mustafa, Ayman G; Zaqout, Sami... more authors ... less authors ( MDPI , 2023 , Article)Neurons in the spinal trigeminal nucleus of a camel were morphologically studied by the Golgi impregnation method. The neurons were classified based on the size and shape of their cell bodies, the density of their dendritic ... -
A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer
Abd El-Aleem, Seham A.; Abd-Elghany, Manal Ismail; Ali Saber, Entesar; Jude, Edward B.; Djouhri, Laiche ( Wiley , 2020 , Article)Chronic venous ulcer (CVU) is a major cause of chronic wounds of lower extremities and presents a significant financial and resource burden to health care systems worldwide. Defects in the vasculature, matrix deposition, ... -
Umbelliferone inhibits spermatogenic defects and testicular injury in lead-intoxicated rats by suppressing oxidative stress and inflammation, and improving Nrf2/HO-1 signaling
Alotaibi, Mohammed F.; Al-Joufi, Fakhria; Seif, Howida S.Abou; Alzoghaibi, Mohammed A.; Djouhri, Laiche; Ahmeda, Ahmad F.; Mahmoud, Ayman M.... more authors ... less authors ( Dove Medical Press , 2020 , Article)© 2020 Alotaibi et al. Introduction: Lead (Pb) is an environmental toxic metal that threatens human health. Umbelliferone (UMB) is a coumarin with known medicinal and protective properties against cytotoxicity. This study ...