Browsing by Author "Houlden, Henry"

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Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity

Habib, Abdella M.; Okorokov, Andrei L.; Hill, Beta Matthew Nicholas; Bras, Jose T.; Lee, Man-Cheung; Li, Shengnan; Gossage, Samuel J.; Drimmelen, Marie van; Houlden, Henry H.; Ramirez, Juan D.; Bennett, David L.H.; Srivastava, Devjit; Cox, James J.... more authors ... less authors ( Elsevier , 2019 , Article)
The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally ...
Molecular basis of FAAH-OUT-associated human pain insensitivity.

Mikaeili, Hajar; Habib, Abdella M; Yeung, Charlix Wai-Lok; Santana-Varela, Sonia; Luiz, Ana P; Panteleeva, Kseniia; Zuberi, Sana; Athanasiou-Fragkouli, Alkyoni; Houlden, Henry; Wood, John N; Okorokov, Andrei L; Cox, James J... more authors ... less authors ( Oxford University Press , 2023 , Article)
Chronic pain affects millions of people worldwide and new treatments are needed urgently. One way to identify novel analgesic strategies is to understand the biological dysfunctions that lead to human inherited pain ...