Browsing by Author "El-Agnaf, Omar"
Now showing items 1-4 of 4
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Cerebrospinal α-Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort
Majbour, Nour K.; Abdi, Ilham Y.; Dakna, Mohammed; Wicke, Tamara; Lang, Elisabeth; Ali Moussa, Houda Y.; Thomas, Mercy A.; Trenkwalder, Claudia; Safieh-Garabedian, Bared; Tokuda, Takahiko; Mollenhauer, Brit; El-Agnaf, Omar... more authors ... less authors ( Wiley , 2021 , Article)Background: Tangible efforts have been made to identify biomarkers for Parkinson's disease (PD) diagnosis and progression, with α-synuclein (α-syn) related biomarkers being at the forefront. Objectives: The objectives of ... -
Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils
Ardah, Mustafa T.; Paleologou, Katerina E.; Lv, Guohua; Menon, Sindhu A.; Abul Khair, Salema B.; Lu, Jia-Hong; Safieh-Garabedian, Bared; Al-Hayani, Abdulmonem A.; Eliezer, David; Li, Min; El-Agnaf, Omar M.A.... more authors ... less authors ( Elsevier , 2015 , Article)Compelling evidence indicates that α-synuclein (α-syn) aggregation plays a central role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies. Identification of compounds that inhibit or reverse the ... -
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
Ardah, Mustafa T; Ghanem, Simona S; Abdulla, Sara A; Lv, Guohua; Emara, Mohamed M; Paleologou, Katerina E; Vaikath, Nishant N; Lu, Jia-Hong; Li, Min; Vekrellis, Konstantinos; Eliezer, David; El-Agnaf, Omar M A... more authors ... less authors ( BMC , 2020 , Article)Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson's disease (PD), multiple system atrophy, and dementia ... -
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
Majbour, Nour K.; Vaikath, Nishant N.; van Dijk, Karin D.; Ardah, Mustafa T.; Varghese, Shiji; Vesterager, Louise B.; Montezinho, Liliana P.; Poole, Stephen; Safieh-Garabedian, Bared; Tokuda, Takahiko; Teunissen, Charlotte E.; Berendse, Henk W.; van de Berg, Wilma D. J.; El-Agnaf, Omar M. A.... more authors ... less authors ( BioMed Central , 2016 , Article)Background Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson’s disease (PD) based on biochemical analysis of blood or CSF. However, neurodegeneration in the brains of PD patients ...