Browsing by Author "Zaqout, Sami"
Now showing items 1-13 of 13
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Abnormal brain structure and behavior in MyD88-deficient mice.
Schroeder, Patricia; Rivalan, Marion; Zaqout, Sami; Krüger, Christina; Schüler, Jutta; Long, Melissa; Meisel, Andreas; Winter, York; Kaindl, Angela M; Lehnardt, Seija... more authors ... less authors ( Elsevier , 2021 , Article)While the original protein Toll in Drosophila melanogaster regulates both host defense and morphogenesis, the role of its ortholog Toll-like receptors (TLRs), the interleukin 1 receptor (IL-1R) family, and the associated ... -
Autosomal Recessive Primary Microcephaly: Not Just a Small Brain
Zaqout, Sami; Kaindl, Angela M ( Frontiers Media , 2022 , Article Review)Microcephaly or reduced head circumference results from a multitude of abnormal developmental processes affecting brain growth and/or leading to brain atrophy. Autosomal recessive primary microcephaly (MCPH) is the prototype ... -
Congenital microcephaly-linked CDK5RAP2 affects eye development
Zaqout, Sami; Ravindran, Ethiraj; Stoltenburg-Didinger, Gisela; Kaindl, Angela M ( Wiley , 2020 , Article)Biallelic mutations in the cyclin-dependent kinase 5 regulatory subunit-associated protein 2 gene CDK5RAP2 cause autosomal recessive primary microcephaly type 3 (MCPH3). MCPH is characterized by intellectual disability and ... -
A Golgi study of neurons in the camel cerebellum (Camelus dromedarius)
Al-Hussain, Saleh M.; Yousuf, Mustafa S.; Hani, Ayat Bani; Zaqout, Sami; Djouhri, Laiche; Mustafa, Ayman G.... more authors ... less authors ( Wiley , 2021 , Article)Neurons in the cerebellar cortex of camels were studied using modified Golgi impregnation methods. Neurons were classified according to their position, morphology of their soma, density and distribution of dendrites, and ... -
Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability
Ravindran, Ethiraj; Gutierrez de Velazco, Cynthia; Ghazanfar, Ali; Kraemer, Nadine; Zaqout, Sami; Waheed, Abdul; Hanif, Mohsan; Mughal, Sadia; Prigione, Alessandro; Li, Na; Fang, Xiang; Hu, Hao; Kaindl, Angela M... more authors ... less authors ( BMJ Publishing Group , 2021 , Article)Minichromosomal maintenance (MCM) complex components 2, 4, 5 and 6 have been linked to human disease with phenotypes including microcephaly and intellectual disability. The MCM complex has DNA helicase activity and is ... -
Immunofluorescence Staining of Paraffin Sections Step by Step.
Zaqout, Sami; Becker, Lena-Luise; Kaindl, Angela M ( Frontiers Media , 2020 , Article)Immunofluorescence staining is the most frequently applied technique to detect and visualize various molecules in biological samples. Many protocols can be found in the literature and the websites of commercial antibody ... -
The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.
Ambrozkiewicz, Mateusz C; Borisova, Ekaterina; Schwark, Manuela; Ripamonti, Silvia; Schaub, Theres; Smorodchenko, Alina; Weber, A Ioana; Rhee, Hong Jun; Altas, Bekir; Yilmaz, Rüstem; Mueller, Susanne; Piepkorn, Lars; Horan, Stephen T; Straussberg, Rachel; Zaqout, Sami; Jahn, Olaf; Dere, Ekrem; Rosário, Marta; Boehm-Sturm, Philipp; Borck, Guntram; Willig, Katrin I; Rhee, JeongSeop; Tarabykin, Victor; Kawabe, Hiroshi... more authors ... less authors ( Springer Nature , 2020 , Article)Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly, and characteristic dysmorphisms. Biallelic mutations of UBE3B, ... -
Neuronal Cell Types in the Anterior Ventral Thalamic Nucleus of the Camel.
Al-Hussain, Saleh M; Albostanji, Shaden A; Mustafa, Ayman G; Zaqout, Sami ( Wiley , 2021 , Article)The anterior ventral nucleus neurons in of the camel brain were morphologically studied by Golgi impregnation method. Two neuronal types of were found in the camel anterior ventral thalamic nucleus, namely, Golgi-type I ... -
Neuronal Cell Types in the Spinal Trigeminal Nucleus of the Camel Brain.
El-Dwairi, Qasim A; Al-Hussain, Saleh M; Banihani, Ayat S; Bataineh, Ziad M; Djouhri, Laiche; Mustafa, Ayman G; Zaqout, Sami... more authors ... less authors ( MDPI , 2023 , Article)Neurons in the spinal trigeminal nucleus of a camel were morphologically studied by the Golgi impregnation method. The neurons were classified based on the size and shape of their cell bodies, the density of their dendritic ... -
Proteome changes in autosomal recessive primary microcephaly
Zaqout, Sami; Mannaa, Atef; Klein, Oliver; Krajewski, Angelika; Klose, Joachim; Luise-Becker, Lena; Elsabagh, Ahmed; Ferih, Khaled; Kraemer, Nadine; Ravindran, Ethiraj; Makridis, Konstantin; Kaindl, Angela M.... more authors ... less authors ( Wiley , 2022 , Article)Background/aim: : Autosomal recessive primary microcephaly (MCPH) is a rare and genetically heterogeneous group of disorders characterized by intellectual disability and microcephaly at birth, classically without further ... -
PTRH2 is Necessary for Purkinje Cell Differentiation and Survival and its Loss Recapitulates Progressive Cerebellar Atrophy and Ataxia Seen in IMNEPD Patients
Picker-Minh, Sylvie; Luperi, Ilaria; Ravindran, Ethiraj; Kraemer, Nadine; Zaqout, Sami; Stoltenburg-Didinger, Gisela; Ninnemann, Olaf; Hernandez-Miranda, Luis R.; Mani, Shyamala; Kaindl, Angela M.... more authors ... less authors ( Springer , 2022 , Article)Homozygous variants in the peptidyl-tRNA hydrolase 2 gene (PTRH2) cause infantile-onset multisystem neurologic, endocrine, and pancreatic disease. The objective is to delineate the mechanisms underlying the core cerebellar ... -
Role of Cdk5rap2 in neocortical inhibition and excitation balance
Zaqout, Sami; Becker, Lena-Luise; Mustafa, Ayman; Kramer, Nadine; Strauss, Ulf; Kaindl, Angela M.... more authors ... less authors ( Qatar University Press , 2020 , Poster)Autosomal recessive primary microcephaly type 3 (MCPH3) is characterized by congenital microcephaly and intellectual disability. Further features include hyperactivity and seizures. The disease is caused by biallelic ... -
Teaching Musculoskeletal Module using dissection videos: feedback from medical students.
Mustafa, Ayman G; Taha, Nour R; Zaqout, Sami; Ahmed, Mohammed Seed ( BMC , 2021 , Article)Over the last two decades many medical schools have been exploring alternatives to hands-on cadaver dissection in teaching anatomy. This study aimed at reporting medical students' feedback on using dissection videos in ...