Browsing by Author "Arafa, Salaheddin"
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Effect of CYP2C19 genetic variants on bleeding and major adverse cardiovascular events in a cohort of Arab patients undergoing percutaneous coronary intervention and stent implantation
Ali, Zainab Omer; Bader, Loulia; Mohammed, Shaaban; Arafa, Salaheddin; Arabi, Abdulrahman; Cavallari, Larisa; Langaee, Taimour; Mraiche, Fatima; Rizk, Nasser; Awaisu, Ahmed; Shahin, Mohamed H.; Elewa, Hazem... more authors ... less authors ( Lippincott Williams and Wilkins , 2022 , Article)Introduction One-third of patients have clopidogrel resistance that may lead to major adverse cardiac events (MACEs). By contrast, it was found that some clopidogrel-treated patients have hyperresponsive platelets that are ... -
Short- and long-term cost-effectiveness analysis of CYP2C19 genotype-guided therapy, universal clopidogrel, versus universal ticagrelor in post-percutaneous coronary intervention patients in Qatar
Sawsan, AlMukdad; Elewa, Hazem; Arafa, Salaheddin; Al-Badriyeh, Daoud ( Elsevier , 2021 , Article)BackgroundPatients having CYP2C19 loss-of-function alleles and receiving clopidogrel are at higher risk of adverse cardiovascular outcomes. Ticagrelor is an effective antiplatelet that is unaffected by the CYP2C19 polymorphism. ...