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Authorzakaria, zain z.
Authorbenslimane, fatiha m.
Authornasrallah, gheyath k.
Authorshurbaji, samar
Authoryounes, nadin n.
AuthorMraiche, Fatima
AuthorDa’as, Sahar I.
Authoryalcin, huseyin c.
Available date2018-10-09T05:53:30Z
Publication Date2018-09-27
Publication NameBioMed Research Internationalen_US
Identifierhttp://dx.doi.org/10.1155/2018/1642684
CitationZakaria, Z. Z., Benslimane, F. M., Nasrallah, G. K., Shurbaji, S., Younes, N. N., Mraiche, F., ... & Yalcin, H. C. (2018). Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity. BioMed Research International, 2018.
ISSN2314-6133
URIhttp://hdl.handle.net/10576/11132
AbstractOver the last decade, the zebrafish (Danio rerio) has emerged as amodel organismfor cardiovascular research.Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish is comparatively low; the embryos are transparent, develop externally, and have high fecundity making them suitable for large-scale genetic screening. More recently, zebrafish embryos have been used for the screening of a variety of toxic agents, particularly for cardiotoxicity testing. Zebrafish has been shown to exhibit physiological responses that are similar to mammals after exposure to medicinal drugs including xenobiotics, hormones, cancer drugs, and also environmental pollutants, including pesticides and heavy metals. In this review, we provided a summary for recent studies that have used zebrafish to investigate themolecularmechanisms of drug-induced cardiotoxicity. More specifically, we focused on the techniques that were exploited by us and others for cardiovascular toxicity assessment and described several microscopic imaging and analysis protocols that are being used for the estimation of a variety of cardiac hemodynamic parameters.
SponsorHuseyin C. Yalcin is supported by Qatar National Research Fund (QNRF), National Priority Research Program NPRP 10-0123-170222,and Qatar University internal funds,QUUGBRC-2017-3 and QUST-BRC-SPR\2017-1. The publication of this article was partially funded by the Qatar National Library.
Languageen
PublisherHindawi Publishing Corporation
Subjectzebrafish
Subjectmicroscopy
Subjecthemodynamics
Subjectteratogenicity
Subjectheart function
Subjectblood flow
Subjectcardiotoxicity
TitleUsing Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity
TypeArticle
Pagination1-10
Volume Number2018
dc.identifier.essn 2314-6141


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