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AuthorSareyeldin, Rasha M
AuthorGupta, Ishita
AuthorAl-Hashimi, Israa
AuthorAl-Thawadi, Hamda A
AuthorAl Farsi, Halema F
AuthorVranic, Semir
AuthorAl Moustafa, Ala-Eddin
Available date2019-05-15T10:49:13Z
Publication Date2019-05-10
Publication NameCancersen_US
Identifierhttp://dx.doi.org/10.3390/cancers11050646
CitationSareyeldin, R.M.; Gupta, I.; Al-Hashimi, I.; Al-Thawadi, H.A.; Al Farsi, H.F.; Vranic, S.; Al Moustafa, A.-E. Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer. Cancers 2019, 11, 646.
URIhttp://hdl.handle.net/10576/11566
AbstractBreast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 (HER2)-enriched (HER2-positive) is characterized by the absence of estrogen and progesterone receptors and overexpression of HER2 receptor, and accounts for 15-20% of all breast cancers. Despite the anti-HER2 and cytotoxic chemotherapy, HER2 subtype is an aggressive disease with significant mortality. Recent advances in molecular biology techniques, including gene expression profiling, proteomics, and microRNA analysis, have been extensively used to explore the underlying mechanisms behind human breast carcinogenesis and metastasis including HER2-positive breast cancer, paving the way for developing new targeted therapies. This review focuses on recent advances on gene expression and miRNA status in HER2-positive breast cancer.
SponsorResearch of Al Moustafa’s and Vranic’s labs have been supported by grants from Qatar University: QUCG-CMED-2018\2019-3, QUCP-CMED-2019-1 and QUST-1-CMED-2019-18.
Languageen
PublisherMDPI
SubjectHER2-positive breast cancer
Subjectbiomarkers
Subjectbreast cancer
Subjectgene expression profiling
SubjectmiRNAs
Subjectmicroarray
TitleGene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer.
TypeArticle
Issue Number5
Volume Number11
dc.identifier.essn 2072-6694


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