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AuthorAgouni, Abdelali
AuthorMostefai, Hadj Ahmed
AuthorLagrue, Anne-Hélène
AuthorSladkova, Martina
AuthorRouet, Philippe
AuthorDesmoulin, Franck
AuthorPechanova, Olga
AuthorMartínez, Maria Carmen
AuthorAndriantsitohaina, Ramaroson
Available date2019-05-23T07:52:52Z
Publication Date2017
Publication NameOxidative Medicine and Cellular Longevityen_US
Identifierhttp://dx.doi.org/10.1155/2017/8536910
CitationAbdelali Agouni, Hadj Ahmed Mostefai, Anne-Hélène Lagrue, et al., “Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (fa/fa),” Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID 8536910, 12 pages, 2017. https://doi.org/10.1155/2017/8536910.
IdentifierArticle ID 8536910
URIhttp://hdl.handle.net/10576/11613
AbstractThe aim of this work was to study the vascular effects of dietary supplementation of a nonalcoholic red wine polyphenol extract, Provinols, in Zucker fatty (ZF) obese rats. ZF or lean rats received diet supplemented or not with Provinols for 8 weeks. Vasoconstriction in response to phenylephrine (Phe) was then assessed in small mesenteric arteries (SMA) and the aorta with emphasis on the contribution of cyclooxygenases (COX). Although no difference in vasoconstriction was observed between ZF and lean rats both in SMA and the aorta, Provinols affected the contribution of COX-derived vasoconstrictor agents. The nonselective COX inhibitor, indomethacin, reduced vasoconstriction in vessels from both groups; however, lower efficacy was observed in Provinols-treated rats. This was associated with a reduction in thromboxane-A2 and 8-isoprostane release. The selective COX-2 inhibitor, NS398, reduced to the same extent vasoconstriction in aortas from ZF and Provinols-treated ZF rats. However, NS398 reduced response to Phe only in SMA from ZF rats. This was associated with a reduction in 8-isoprostane and prostaglandin-E release. Paradoxically, Provinols decreased COX-2 expression in the aorta, while it increased its expression in SMA. We provide here evidence of a subtle and paradoxical regulation of COX pathway by Provinols vessels from obese rats to maintain vascular tone within a physiological range.
Languageen
PublisherHindawi Publishing Corporation
SubjectPolyphenols
Subjectobesity
Subjectvascular function
SubjectCyclooxygenases
TitleParadoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (/)
TypeArticle
Volume Number2017


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