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المؤلفAgouni, Abdelali
المؤلفMostefai, Hadj Ahmed
المؤلفLagrue, Anne-Hélène
المؤلفSladkova, Martina
المؤلفRouet, Philippe
المؤلفDesmoulin, Franck
المؤلفPechanova, Olga
المؤلفMartínez, Maria Carmen
المؤلفAndriantsitohaina, Ramaroson
تاريخ الإتاحة2019-05-23T07:52:52Z
تاريخ النشر2017
اسم المنشورOxidative Medicine and Cellular Longevityen_US
المعرّفhttp://dx.doi.org/10.1155/2017/8536910
الاقتباسAbdelali Agouni, Hadj Ahmed Mostefai, Anne-Hélène Lagrue, et al., “Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (fa/fa),” Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID 8536910, 12 pages, 2017. https://doi.org/10.1155/2017/8536910.
المعرّفArticle ID 8536910
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11613
الملخصThe aim of this work was to study the vascular effects of dietary supplementation of a nonalcoholic red wine polyphenol extract, Provinols, in Zucker fatty (ZF) obese rats. ZF or lean rats received diet supplemented or not with Provinols for 8 weeks. Vasoconstriction in response to phenylephrine (Phe) was then assessed in small mesenteric arteries (SMA) and the aorta with emphasis on the contribution of cyclooxygenases (COX). Although no difference in vasoconstriction was observed between ZF and lean rats both in SMA and the aorta, Provinols affected the contribution of COX-derived vasoconstrictor agents. The nonselective COX inhibitor, indomethacin, reduced vasoconstriction in vessels from both groups; however, lower efficacy was observed in Provinols-treated rats. This was associated with a reduction in thromboxane-A2 and 8-isoprostane release. The selective COX-2 inhibitor, NS398, reduced to the same extent vasoconstriction in aortas from ZF and Provinols-treated ZF rats. However, NS398 reduced response to Phe only in SMA from ZF rats. This was associated with a reduction in 8-isoprostane and prostaglandin-E release. Paradoxically, Provinols decreased COX-2 expression in the aorta, while it increased its expression in SMA. We provide here evidence of a subtle and paradoxical regulation of COX pathway by Provinols vessels from obese rats to maintain vascular tone within a physiological range.
اللغةen
الناشرHindawi Publishing Corporation
الموضوعPolyphenols
الموضوعobesity
الموضوعvascular function
الموضوعCyclooxygenases
العنوانParadoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (/)
النوعArticle
رقم المجلد2017


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