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AuthorMaamoun, Hatem
AuthorAbdelsalam, Shahenda S
AuthorZeidan, Asad
AuthorKorashy, Hesham M
AuthorAgouni, Abdelali
Available date2019-05-29T06:50:22Z
Publication Date2019-04-01
Publication NameInternational Journal of Molecular Sciencesen_US
Identifierhttp://dx.doi.org/10.3390/ijms20071658
CitationMaamoun, H.; Abdelsalam, S.S.; Zeidan, A.; Korashy, H.M.; Agouni, A. Endoplasmic Reticulum Stress: A Critical Molecular Driver of Endothelial Dysfunction and Cardiovascular Disturbances Associated with Diabetes. Int. J. Mol. Sci. 2019, 20, 1658.
ISSN1661-6596
URIhttp://hdl.handle.net/10576/11619
AbstractPhysical inactivity and sedentary lifestyle contribute to the widespread epidemic of obesity among both adults and children leading to rising cases of diabetes. Cardiovascular disease complications associated with obesity and diabetes are closely linked to insulin resistance and its complex implications on vascular cells particularly endothelial cells. Endoplasmic reticulum (ER) stress is activated following disruption in post-translational protein folding and maturation within the ER in metabolic conditions characterized by heavy demand on protein synthesis, such as obesity and diabetes. ER stress has gained much interest as a key bridging and converging molecular link between insulin resistance, oxidative stress, and endothelial cell dysfunction and, hence, represents an interesting drug target for diabetes and its cardiovascular complications. We reviewed here the role of ER stress in endothelial cell dysfunction, the primary step in the onset of atherosclerosis and cardiovascular disease. We specifically focused on the contribution of oxidative stress, insulin resistance, endothelial cell death, and cellular inflammation caused by ER stress in endothelial cell dysfunction and the process of atherogenesis.
SponsorQatar University internal grants No. QUCG-CPH-2018\2019-2, QUST-1-CPH-2018-1 and QUST-1-CPH-2018-2 .The publication of this article was funded by Qatar National Library.
Languageen
PublisherMDPI
Subjectatherosclerosis
Subjectdiabetes
Subjectendoplasmic reticulum stress
Subjectendothelial dysfunction
Subjectunfolded protein response
TitleEndoplasmic Reticulum Stress: A Critical Molecular Driver of Endothelial Dysfunction and Cardiovascular Disturbances Associated with Diabetes.
TypeArticle
Issue Number7
Volume Number20
ESSN1422-0067


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