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AuthorAgouni, Abdelali
AuthorParray, Aijaz S
AuthorAkhtar, Naveed
AuthorMir, Fayaz A
AuthorBourke, Paula J
AuthorJoseph, Sujata
AuthorMorgan, Deborah M
AuthorSantos, Mark D
AuthorWadiwala, Muhammad F
AuthorKamran, Saadat
AuthorSivaraman, Siveen K
AuthorShuaib, Ashfaq
Available date2019-05-30T08:53:39Z
Publication Date2019-03-19
Publication NameFrontiers in Neurologyen_US
Identifierhttp://dx.doi.org/10.3389/fneur.2019.00251
CitationAgouni A, Parray AS, Akhtar N, Mir FA, Bourke PJ, Joseph S, Morgan DM, Santos MD, Wadiwala MF, Kamran S, Sivaraman SK and Shuaib A (2019) There Is Selective Increase in Pro-thrombotic Circulating Extracellular Vesicles in Acute Ischemic Stroke and Transient Ischemic Attack: A Study of Patients From the Middle East and Southeast Asia. Front. Neurol. 10:251. doi: 10.3389/fneur.2019.00251
URIhttp://hdl.handle.net/10576/11620
AbstractStroke attacks were found to be present at a younger age in patients from Southeast Asia (SE) and the Middle East (ME) resident in the state of Qatar. Extracellular vesicles (EVs), which are small membrane vesicles with pro-thrombotic properties, may contribute to the high risk of stroke in this population. Thus, total and cell-specific medium size EVs were counted by flow cytometry in platelet-free plasma from healthy volunteers and patients with transient ischemic attacks (TIA) and acute ischemic stroke (AIS) from SE and ME. Acutely, within 48 h of attacks, there was an increase in total endothelial EVs in TIA (6.73 ± 1.77; = 0.0156; = 21) and AIS (11.23 ± 1.95; = 0.0007; = 66) patients compared to controls (2.04 ± 0.78; = 24). Similar increases were also evident in EVs originating from platelets, erythrocytes, granulocytes, and leukocytes. Compared to controls, there was also an increase in EVs derived from activated endothelial cells, platelets, granulocytes, leukocytes, and pro-coagulant EVs (Annexin V) at 5 and 30-days following the acute events, while a decrease was observed in erythrocyte-derived EVs. This is the first study characterizing EVs in TIA and AIS patients from ME and SE showing an increase in EVs associated with endothelial and platelet cell activation, which may contribute to the elevated risk of stroke at a younger age in this population.
SponsorQatar University high collaborative grant (QUCG-CPH-2018\2019-2)
Languageen
PublisherFrontiers Media
Subjectacute ischemic stroke (AIS)
Subjectbiomarkers
Subjectextracellular vesicles (EVs)
Subjectthrombosis
Subjecttransient ischemic attacks (TIA)
TitleThere Is Selective Increase in Pro-thrombotic Circulating Extracellular Vesicles in Acute Ischemic Stroke and Transient Ischemic Attack: A Study of Patients From the Middle East and Southeast Asia.
TypeArticle
Volume Number10
ESSN1664-2295


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