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AuthorAl Moustafa, Ala-Eddin
AuthorAhmed, Hussain G
AuthorWulf, Gerburg
AuthorSultan, Ali A
Available date2019-10-16T07:47:17Z
Publication Date2019
Publication NameFrontiers in Oncologyen_US
Identifierhttp://dx.doi.org/10.3389/fonc.2018.00528
CitationAl Moustafa A-E, Ahmed HG, Wulf G and Sultan AA (2018) Editorial: EBV-Associated Carcinomas: Presence, Role, and Prevention Strategies. Front. Oncol. 8:528. doi: 10.3389/fonc.2018.00528
URIhttp://hdl.handle.net/10576/12131
AbstractThis special issue addresses an important topic related to the role of Epstein-Barr virus (EBV) in human carcinomas initiation and progression, which is one of the most common viral infections worldwide. Today, the relationship between EBV infection and several types of human lymphomas is clearly established, including Hodgkin and Burkitt's lymphoma; meanwhile, it was recently pointed out that EBV is present in nasopharyngeal carcinomas as well as other epithelial cancers (1). EBV is ubiquitous human herpesvirus 4, its genome codes more than 85 proteins of which only few are well-understood; More specifically, six nuclear antigens (EBNA: 1, 2, 3A, 3B, 3C, and LP); three latent membrane proteins/genes (LMP: 1, 2A, 2B) as well as small non-polyadenylated RNAs, EBERs 1 and 2 in addition to few microRNAs have been identified so far, as key regulators, of the oncogenic activity of this virus (2, 3). Present estimates indicate that EBV causes 200,000 new cancer cases annually, accounting for ~2% of cancers worldwide (Cancer Research UK). On the other hand, it is important to emphasize that recent investigations have revealed the possible involvement of EBV in other cancers such as cervical, gliomas, and breast, which are highlighted in this issue.
SponsorThis work is supported by Qatar University grants# GCC-2017-002 QU/KU and QUCG-CMED-20182019-3.
Languageen
PublisherFrontiers Media
SubjectEBV vaccine
SubjectEpstein-Barr virus
Subjectbreast cancer
Subjectcervical cancer
Subjectepithelial to mesenchymal transition
TitleEditorial: EBV-Associated Carcinomas: Presence, Role, and Prevention Strategies.
TypeOther
Pagination528
Issue Number8
Volume Number16
ESSN2234-943X


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