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AuthorAshammakhi N.
AuthorWesseling-Perry K.
AuthorHasan A.
AuthorElkhammas E.
AuthorZhang Y.S.
Available date2019-11-03T11:47:37Z
Publication Date2018
Publication NameKidney International
ISSN852538
URIhttp://dx.doi.org/10.1016/j.kint.2018.06.034
URIhttp://hdl.handle.net/10576/12212
AbstractThe organs-on-a-chip technology has shown strong promise in mimicking the complexity of native tissues in vitro and ex vivo, and recently significant advances have been made in applying this technology to studies of the kidney and its diseases. Individual components of the nephron, including the glomerulus, proximal tubule, and distal tubule/medullary collecting duct, have been successfully mimicked using organs-on-a-chip technology and yielding strong promises in advancing the field of ex vivo drug toxicity testing and augmenting renal replacement therapies. Although these models show promise over 2-dimensional cell systems in recapitulating important nephron features in vitro, nephron functions, such as tubular secretion, intracellular metabolism, and renin and vitamin D production, as well as prostaglandin synthesis are still poorly recapitulated in on-chip models. Moreover, construction of multiple-renal-components-on-a-chip models, in which various structures and cells of the renal system interact with each other, has remained a challenge. Overall, on-chip models show promise in advancing models of normal and pathological renal physiology, in predicting nephrotoxicity, and in advancing treatment of chronic kidney diseases. � 2018
SponsorAH acknowledges GCC-2017-005 grant from Qatar University under the GCC research program and the NPRP grant (NPRP 9-144-2-021) from the Qatar National Research Fund (a member of The Qatar Foundation). The statements made herein are solely the responsibility of the authors. YSZ acknowledges funding from the National Institutes of Health (K99CA201603, R21EB025270) and the New England Anti-Vivisectio Society. NA acknowledges funds received from the Biotechnology Research Center, Libyan Authority of Research Science and Technology and UNESCO. The authors thank Mr. Mohammed Xohdy for producing some of illustrations in this paper.
Languageen
PublisherElsevier B.V.
Subjectkidney
Subjectmicrofluidics
Subjectmicrophysiological systems
Subjectorgan-on-a-chip
Subjecttissue engineering
TitleKidney-on-a-chip: untapped opportunities
TypeArticle Review
Pagination1073 - 1086
Issue Number6
Volume Number94


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