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AuthorKarin-Kujundzic, Valentina
AuthorKardum, Vedran
AuthorMarija Sola, Ida
AuthorPaic, Frane
AuthorSkrtic, Anita
AuthorSkenderi, Faruk
AuthorSerman, Alan
AuthorNikuseva-Martic, Tamara
AuthorVranic, Semir
AuthorSerman, Ljiljana
Available date2019-12-01T10:39:15Z
Publication Date2019-11-22
Publication NameAPMISen_US
AbstractDishevelled family proteins (DVL1, DVL2 and DVL3) are cytoplasmic mediators involved in canonical and non-canonical Wnt signaling that are important for embryonic development. Since Wnt signaling promotes cell proliferation and invasion, its increased activation is associated with cancer development as well. To get deeper insight into the behavior of Dishevelled proteins in cancer, we studied their expression in serous ovarian carcinomas [both low- (LGSC) and high-grade (HGSC)], and HGSC cell lines OVCAR5, OVCAR8 and OVSAHO. DVL protein expression in serous ovarian carcinomas tissues was analyzed using immunohistochemistry while DVL protein and mRNA expressions in HGSC cell lines were analyzed using western blot and quantitative real-time PCR. DVL1 protein expression was significantly higher in LGSC compared with normal ovarian tissue, while DVL3 was overexpressed in both LGSC and HGSC. DVL2 and DVL3 protein expression was higher in HGSC cell lines when compared with normal control cell line while DVL1, DVL2, and DVL3 mRNA expression was significantly increased only in OVSAHO cell line. Survival analysis revealed no significant impact of DVL proteins on patients' outcome. Our data show an active involvement of Dishevelled family proteins in serous ovarian carcinomas. Further studies should confirm the clinical relevance of these observations.
SponsorEuropean Union through the Europe Regional Development Fund, Operational Programme Competitiveness and Cohesion, under grant agreement No. KK. Qatar University: QUSD-CMED-2018-2
SubjectDishevelled proteins
SubjectWnt signaling pathway
Subjectovarian carcinoma cell lines
Subjectserous carcinoma
TitleDishevelled family proteins in serous ovarian carcinomas: A clinicopathologic and molecular study

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