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AuthorShkoor, Mohanad
AuthorSu, Haw‐Lih
AuthorAhmed, Suzan
AuthorHegazy, Sarah
Available date2019-12-23T07:11:30Z
Publication Date2019-01-01
Publication NameJournal of Heterocyclic Chemistryen_US
CitationShkoor, M., Su, H.-L., Ahmed, S., Hegazy, S. Synthesis of 5-oxo-5H-chromeno[3,4-c]pyridine-1-carbonitriles and features of their NMR spectra (2019) Journal of Heterocyclic Chemistry, .
AbstractTwo different methods leading to 5-oxo-5H-chromeno[3,4-c]pyridine-1-carbonitriles were investigated. Reactions of 3-aminocrotonirile with substituted salicylaldehydes provided 5-oxo-5H-chromeno[3,4-c]pyridine-1-carbonitriles with the same substituent on positions 2 and 4 of the system. The reaction of 3-aminocrotonirile with variety of substituted 3-acetylcoumarins lead to 5-oxo-5H-chromeno[3,4-c]pyridine-1-carbonitriles with different substituents on positions 2 and 4. The structures of the products were confirmed by spectroscopic methods. The presence of nitrile moiety in the structures with fixed geometry caused the highly downfield shift of the aromatic proton at position 10 in 1H NMR spectrum. The electronic factor of the substituents caused variation of this downfield shift.
SponsorThis work was supported by Qatar University Grant (QUST‐1‐CAS‐2018‐31). The findings achieved herein are solely the responsibility of the authors. We thank Central Laboratories Unit, Qatar University for their support in compounds analysis.
SubjectNMR spectra
TitleSynthesis of 5-oxo-5H-chromeno[3,4-c]pyridine-1-carbonitriles and features of their NMR spectra
elsevier.identifier.scopusid SCOPUS_ID:85075726068

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