Show simple item record

AuthorAl-Khelaifi, Fatima
AuthorDiboun, Ilhame
AuthorDonati, Francesco
AuthorBotrè, Francesco
AuthorAbraham, David
AuthorHingorani, Aroon
AuthorAlbagha, Omar
AuthorGeorgakopoulos, Costas
AuthorSuhre, Karsten
AuthorYousri, Noha A
Available date2020-01-14T05:07:51Z
Publication Date2019-12-01
Publication NameScientific Reportsen_US
Identifierhttp://dx.doi.org/10.1038/s41598-019-56496-7
CitationAl-Khelaifi, F., Diboun, I., Donati, F. et al. Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance. Sci Rep 9, 19889 (2019) doi:10.1038/s41598-019-56496-7
URIhttp://hdl.handle.net/10576/12535
AbstractGenetic research of elite athletic performance has been hindered by the complex phenotype and the relatively small effect size of the identified genetic variants. The aims of this study were to identify genetic predisposition to elite athletic performance by investigating genetically-influenced metabolites that discriminate elite athletes from non-elite athletes and to identify those associated with endurance sports. By conducting a genome wide association study with high-resolution metabolomics profiling in 490 elite athletes, common variant metabolic quantitative trait loci (mQTLs) were identified and compared with previously identified mQTLs in non-elite athletes. Among the identified mQTLs, those associated with endurance metabolites were determined. Two novel genetic loci in FOLH1 and VNN1 are reported in association with N-acetyl-aspartyl-glutamate and Linoleoyl ethanolamide, respectively. When focusing on endurance metabolites, one novel mQTL linking androstenediol (3alpha, 17alpha) monosulfate and SULT2A1 was identified. Potential interactions between the novel identified mQTLs and exercise are highlighted. This is the first report of common variant mQTLs linked to elite athletic performance and endurance sports with potential applications in biomarker discovery in elite athletic candidates, non-conventional anti-doping analytical approaches and therapeutic strategies.
Languageen
PublisherNature Research
SubjectmGWAS, elite athletes
TitleMetabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance.
TypeArticle
Issue Number1
Volume Number9
ESSN2045-2322


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record