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AuthorKord-Varkaneh, H.
AuthorKord-Varkaneh, Hamed
AuthorRinaldi, Giulia
AuthorHekmatdoost, Azita
AuthorFatahi, Somaye
AuthorTan, Shing Cheng
AuthorShadnoush, Mahdi
AuthorKhani, Vahid
AuthorMousavi, Seyed Mohammad
AuthorZarezadeh, Meysam
AuthorSalamat, Shekoufeh
AuthorBawadi, Hiba
AuthorRahmani, Jamal
Available date2020-01-14T05:29:31Z
Publication Date2020-01-01
Publication NameAgeing Research Reviewsen_US
Identifierhttp://dx.doi.org/10.1016/j.arr.2019.100996
CitationKord-Varkaneh H, Rinaldi G, Hekmatdoost A, Fatahi S, Tan SC, Shadnoush M, Khani V, Mousavi SM, Zarezadeh M, Salamat S, Bawadi H, Rahmani J. The influence of vitamin D supplementation on IGF-1 levels in humans: A systematic review and meta-analysis. Ageing Res Rev. 2020 Jan;57:100996. doi: 10.1016/j.arr.2019.100996.
ISSN1568-1637
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076192928&origin=inward
URIhttp://hdl.handle.net/10576/12537
Abstract© 2019 Elsevier B.V. Background: Inconsistencies exist with regard to influence of vitamin D supplementation on IGF-1 levels. The inconsistencies could be attributed to several factors, such as dosage and duration of intervention, among others. To address these inconsistencies, this study was conducted to determine the impact of vitamin D supplementation on IGF-1 levels through a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: A comprehensive systematic search was carried out in PubMed/MEDLINE, Web of Science, SCOPUS and Embase for RCTs that investigated the impact of vitamin D intake on circulating IGF-1 levels from inception until June 2019. Weighted mean difference (WMD) with the 95 % CI were applied for estimating combined effect size. Subgroup analysis was performed to specify the source of heterogeneity among studies. Results: Pooled results from eight studies demonstrated an overall non-significant increase in IGF-1 following vitamin D supplementation (WMD: 4 ng/ml, 95 % CI: −4 to 11). However, a significant degree of heterogeneity among studies was observed (I2 = 66 %). The subgroup analyses showed that vitamin D dosage of ≤1000 IU/day (WMD: 10 ng/ml) significantly increased IGF-1 compared to the vitamin D dosage of <1000 IU/day (WMD: −1 ng/ml). Moreover, intervention duration ≤12 weeks (WMD: 11 ng/ml) significantly increased IGF-1 compared to intervention duration <12 weeks (WMD: −3 ng/ml). In the epidemiological cohort study, participants under 60 years of age with a higher dietary vitamin D intake had significantly higher IGF-1 levels when compared to those with lower dietary vitamin D intake in second categories. Conclusion: The main results indicate a non-significant increase in IGF-1 following vitamin D supplementation. Additionally, vitamin D dosages of <1000 IU/day and intervention durations of <12 weeks significantly raised IGF-1 levels.
SponsorThe authors sincerely thank Shahid Beheshti University of Medical Sciences for all moral and material supports. This study was supported by grants from the Student Research Committee, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran (Grant’s ID: 1398/3995).
Languageen
PublisherElsevier
Subject25-Hydroxyvitamin D
SubjectIGF-1
SubjectVitamin D
TitleThe influence of vitamin D supplementation on IGF-1 levels in humans: A systematic review and meta-analysis
TypeArticle
Volume Number57
elsevier.identifier.scopusid SCOPUS_ID:85076192928
ESSN1872-9649


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