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AuthorTaylan, Osman
AuthorYilmaz, Mustafa Tahsin
AuthorBalubaid, Mohammed
AuthorAlamoudi, Rami
AuthorEl-Obeid, Tahra
AuthorDertli, Enes
AuthorŞahin, Engin
AuthorBakhsh, Ahmed
AuthorHerrera-Viedma, Enrique
Available date2020-02-16T10:02:45Z
Publication Date2020-02-01
Publication NameInternational Journal of Ecosystems and Ecology Science (IJEES)en_US
Identifierhttp://dx.doi.org/10.31407/ijees10.1
CitationTaylana, Osman et. al. Machine Learning Application for Optimizing Asymmetrical Reduction of Acetophenone Employing Complete Cell of Lactobacillus Senmaizuke as an Environmentally Friendly Approach. International Journal of Ecosystems and Ecology Science (IJEES). Vol. 10 (1), 123-136 (2020)
ISSN2224-4980
URIhttps://doi.org/10.31407/ijees
URIhttp://hdl.handle.net/10576/12895
AbstractRecently, optimization of the bioreduction reactions by optimization methodologies has gained special interest as these reactions are affected by several extrinsic factors that should be optimized for higher yields. An important example for these kinds of reactions is the complete cell implications for the bioreduction of prochiral ketones in which the culture parameters play crucial roles. Such biocatalysts provide environmentally friendly and clean methodology to perform reactions under mild conditions with high conversion rates. In the present work, at the first step the Lactobacillus senmaizuke was isolated from sourdough and the complete cell application of Lactobacillus senmaizuke for the bioreduction of acetophenone was optimized by an Artificial Neural networks (ANNs) to achieve the highest enantiomeric excess (EE, %). The culture parameters, pH, temperature, incubation period and agitation speed were the experimental factors that were optimized to maximize EE (%) by machine learning algorithm of Artificial Intelligence modeling and the best conditions to maximize EE (95.5 %) were calculated to be pH of 5.7, temperature of 35 ºC, incubation period of 76 h and agitation speed of 240 rpm with very low sum of squared error value (0.611236 %) to bioreduce acetophenone using complete cell of Lactobacillus senmaizuke as a sourdough isolate GRAS microbial species. Accordingly, The ANN was employed to correctly establish the enantiomeric excess values of the specimen with an average absolute error 0.080739 %.
SponsorKing Abdulaziz university, under grant No. (135 -197 - D1439)
Languageen
PublisherHysen MANKOLLI, Earth System Science Interdisciplinary Center (ESSIC)
SubjectSourdough
SubjectAsymmetric bioreduction
SubjectBiocatalyst
SubjectChirality
SubjectMachine learning
SubjectANNs
SubjectBiotransformation
TitleMachine Learning Application for Optimizing Asymmetrical Reduction of Acetophenone Employing Complete Cell of Lactobacillus Senmaizuke as an Environmentally Friendly Approach
TypeArticle
Pagination123 - 136
Issue Number1
Volume Number10


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