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AuthorShaito, Abdullah
AuthorPosadino, Anna Maria
AuthorYounes, Nadin
AuthorHasan, Hiba
AuthorHalabi, Sarah
AuthorAlhababi, Dalal
AuthorAl-Mohannadi, Anjud
AuthorAbdel-Rahman, Wael
AuthorEid, Ali
AuthorNasrallah, Gheyath
AuthorPintus, Gianfranco
Available date2020-03-22T09:32:21Z
Publication Date2020-03-18
Publication NameInternational Journal of Molecular Sciencesen_US
Identifierhttps://doi.org/10.3390/ijms21062084
CitationShaito, A.; Posadino, A.M.; Younes, N.; Hasan, H.; Halabi, S.; Alhababi, D.; Al-Mohannadi, A.; Abdel-Rahman, W.M.; Eid, A.H.; Nasrallah, G.K.; Pintus, G. Potential Adverse Effects of Resveratrol: A Literature Review. Int. J. Mol. Sci. 2020, 21, 2084.
ISSN1661-6596
URIhttp://hdl.handle.net/10576/13476
AbstractDue to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective e ects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but di erences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective e ects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse e ects were reported following consumption of RE; therefore, extensive future studies on the long-term e ects, as well as the in vivo adverse e ects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side e ects. In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.
Languageen
PublisherMDPI
Subjectresveratrol
Subjectbiphasic
Subjectanticancer
Subjectreactive oxygen species (ROS)
Subjectoxidative DNA damage
Subjectantioxidant effects
Subjectpro-oxidant effects
TitlePotential Adverse E ects of Resveratrol: A Literature Review
TypeArticle
Volume Number21
ESSN1422-0067


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