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AuthorToffaha A.
AuthorEl Ansari W.
AuthorRamzee A.F.
AuthorAfana M.
AuthorAljohary H.
Available date2020-04-01T06:54:49Z
Publication Date2019
Publication NameAnnals of Medicine and Surgery
ISSN20490801
URIhttp://dx.doi.org/10.1016/j.amsu.2019.10.034
URIhttp://hdl.handle.net/10576/13648
AbstractBackground Varicella zoster virus presents clinically as primary (chickenpox) or secondary (herpes zoster) infection. Cutaneous and extracutaneous dissemination may occur, usually in immunocompromised patients. VZV hepatitis that progresses to fulminant hepatic failure is very rare and fatal. To the best of our knowledge, 9 cases have been reported to date, of which 7 were in immunocompromised adults, and only one patient was on short duration steroid therapy. Presentation of case We present a 26-year old man who was admitted initially with acute abdomen as query persistent biliary colic. Later, he showed clinical and laboratory findings of VZV hepatitis that progressed rapidly despite maximal medical ICU support and he expired on day 3 of admission. Conclusions Acute VZV infection may present as fulminant hepatitis. The presentation may initially be challenging for the diagnosis and should be considered if the patient has been in contact with a sick case. Low dose corticosteroid could carry a risk for fatal VZV fulminant hepatitis and should be used very cautiously especially with VZV patients’ contacts. Further causative relationships remain to be established.
Languageen
PublisherElsevier Ltd
SubjectBiliary colic
SubjectCase report
SubjectFulminant acute hepatic failure
SubjectHepatitis
SubjectLiver failure
TitleRare presentation of primary varicella zoster as fatal fulminant hepatitis in adult on low-dose,short-term steroid: Case report
TypeArticle
Pagination115-117
Volume Number48


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