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AuthorHussain R.A.
AuthorBadshah A.
AuthorAhmed N.
AuthorPezzuto J.M.
AuthorKondratyuk T.P.
AuthorPark E.-J.
AuthorHussain I.
Available date2020-04-23T14:21:31Z
Publication Date2019
Publication NamePolyhedron
ISSN2775387
URIhttp://dx.doi.org/10.1016/j.poly.2019.05.027
URIhttp://hdl.handle.net/10576/14320
AbstractIn this article we have comprehensively reported the synthesis, complete chemical characterization (FTIR, multinuclear NMR, single crystal XRD, CHNS, AAS) and biological applications of seventeen ferrocene incorporated selenoureas. Biological applications include comparative DNA binding studies (with, cyclic voltammetry), antioxidant activities (DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging), anti-inflammatory activities (nitrite inhibition), phase I enzyme inhibition activities (aromatase inhibition), phase II enzyme induction studies (quinone reductase induction) and cytotoxic studies against neuroblastoma (MYCN2 and SK-N-SH), liver cancer (Hepa 1c1c7) breast cancer (MCF-7) and human cervical carcinoma HeLa cells (ATCC® CCL-2). All the compounds showed decent structure dependent biological applications.
SponsorWe are thankful to Higher Education Commission Islamabad, Pakistan and Pakistan Academy of Sciences for financial support. Appendix A
Languageen
PublisherElsevier Ltd
SubjectCytotoxicity
SubjectEnzymology
SubjectFerrocene
SubjectFree radicals
SubjectSelenourea
TitleSynthesis, characterization and biological applications of selenoureas having ferrocene and substituted benzoyl functionalities
TypeArticle
Pagination24-Dec
Volume Number170


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