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AuthorAshammakhi N.
AuthorElkhammas E.
AuthorHasan A.
Available date2020-04-27T08:34:20Z
Publication Date2019
Publication NameJournal of Biomedical Materials Research - Part B Applied Biomaterials
ResourceScopus
ISSN15524973
URIhttp://dx.doi.org/10.1002/jbm.b.34292
URIhttp://hdl.handle.net/10576/14566
AbstractOrgan‐on‐a‐chip platforms have recently seen tremendous progress. They have found potential applications in the study of physiology and pathology of tissues, drug toxicity, and development of tissue models for replacement of animal studies. However, their potential role in organ transplantation has hardly been discussed, so far. Organ transplantation represents a major medical advancement of the twenty‐first century, yet it suffers from limitation due to the shortage of organ supply. Very often, organs harvested from donor's body are deemed non‐usable because of being damaged or “marginal”. Recently, developments of bioartificial devices such as artificial placenta and renal assist‐devices have shown that it is possible to develop novel bioartificial organ support systems that can support the healing of damaged or marginal organs prior to their transplantation. In the current article, we introduce a novel concept for building bioartificial organ assist devices and systems by integrating arrays of numerous organ‐on‐a‐chip platforms. The new system can be used in organ repair centers as means for temporary organ support and functional enhancement. We have also briefly reviewed the relevant organ‐on‐a‐chip platforms developed so far, and related literature to form a basis for developing our new concept, device and its application. The proposed system may help to increase the number of organs available for transplantation and improve transplantation outcomes. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2006–2018, 2019.
SponsorAH acknowledges GCC-2017-005 grant from Qatar University under the GCC research program and the NPRP grant [NPRP 9-144-3-021] from the Qatar National Research Fund (a member of The Qatar Foundation). Authors thank Professor Dimitrios Stamatialis, Bioartificial organs, Department of Biomaterials Science and Technology, Faculty of Science and Technology, University of Twente, The Netherlands for his critical reading, comments and feedback on the manuscript.
Languageen
PublisherJohn Wiley and Sons Inc.
Subjectmicrofluidics
organ repair
organ-on-a-chip
transplantation
TitleTranslating advances in organ-on-a-chip technology for supporting organs
TypeArticle Review
Pagination2006-2018
Issue Number6
Volume Number107


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