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AuthorUr Rehman S.R.
AuthorAugustine R.
AuthorZahid A.A.
AuthorAhmed R.
AuthorHasan A.
Available date2020-04-27T08:34:22Z
Publication Date2019
Publication NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN1557170X
URIhttp://dx.doi.org/10.1109/EMBC.2019.8857341
URIhttp://hdl.handle.net/10576/14599
AbstractChronic wound or slow healing of a wound is one of the serious complications in diabetic patients. The decrease in the proliferation and migration of cells such as keratinocytes and fibroblasts is the major reason for the development of such chronic wounds in a diabetic patient. Therefore, designing a wound dressing patch using a biodegradable hydrogel, which can provide a sustained release/delivery of active agents that can support cell proliferation and cell migration, will be highly beneficial for promoting diabetic wound healing. Multiple evidences from both in-vitro and in-vivo studies have shown that graphene oxide (GO) and reduced graphene oxide promote wound healing by promoting migration and proliferation of keratinocyte cells. In addition, GO possesses angiogenic property. Gelatin methacrylate (GelMA) based hydrogels display excellent hydrophilic properties due to the presence of hydrophilic amino, amido, carboxyl, and hydroxyl groups in the polymer chains, which gives them highly porous, soft and flexible structure. In this work, we report the development of hydrogel dressing incorporated with GO to improve wound healing by increasing the proliferation and migration of cells. - 2019 IEEE.
SponsorThis article was made possible by the NPRP9-144-3-021 grant funded by the Qatar National Research Fund (a part of Qatar Foundation)
Languageen
PublisherInstitute of Electrical and Electronics Engineers Inc.
SubjectNitric oxide
SubjectNitric Oxide Donors
SubjectOxide release
TitleGraphene Oxide Loaded Hydrogel for Enhanced Wound Healing in Diabetic Patients
TypeConference Paper
Pagination3943-3946


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