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AuthorHamadeh, IS
AuthorShahin, MH
AuthorLima, SM
AuthorOliveira, F
AuthorWilson, L
AuthorKhalifa, SI
AuthorLangaee, TY
AuthorCooper-DeHoff, RM
AuthorCavallari, LH
AuthorJohnson, JA
Available date2021-05-20T04:35:57Z
Publication Date2016
Publication NameClinical and Translational Science
ResourceScopus
ISSN17528054
URIhttp://dx.doi.org/10.1111/cts.12385
URIhttp://hdl.handle.net/10576/18432
AbstractGenotype-based algorithms that include VKORC1 and CYP2C9 genotypes are less predictive of warfarin dose variability in Africans as opposed to Europeans. Polymorphisms in GGCX, FPGS, or STX1B are associated with warfarin dose requirements in African-Americans. We sought to determine if they influenced warfarin dose in European-Americans, and another African population, specifically Egyptians. We genotyped 529 adults (n = 325 European-Americans, 204 Egyptians) on a stable warfarin dose for GGCX rs12714145 and rs10654848, FPGS rs7856096, and STX1B rs4889606. Rs12714145, rs10654848, and rs7856096 were not associated with warfarin dose, whereas STX1B rs4889606 was a significant determinant in univariate analysis (P < 0.0001) in both cohorts. However, STX1B rs4889606 was in high linkage disequilibrium with VKORC1-1639 G>A, and was no longer significant after including VKORC1-1639 G>A in the regression model. Based on these data, the polymorphisms do not appear to influence, in a clinically important way, warfarin dose requirements in European-Americans and Egyptians.
SponsorThis work was supported in part by National Institutes of Health grant GM074492
Languageen
PublisherBlackwell Publishing Ltd
Subjectadenine
guanine
protein STX1B
protein VKORC1
tetrahydrofolate synthase
unclassified drug
vitamin K dependent carboxylase
vitamin K epoxide reductase
warfarin
glutamyl carboxylase
ligase
microsatellite DNA
peptide synthase
STX1B protein, human
syntaxin 1
tetrahydrofolate synthase
warfarin
adult
aged
Article
cerebrovascular accident
cohort analysis
controlled study
dose response
drug dose reduction
Egyptian
European American
gene linkage disequilibrium
genetic association
genotype
human
maintenance drug dose
major clinical study
priority journal
single nucleotide polymorphism
venous thromboembolism
Caucasian
Egypt
female
genetics
male
middle aged
regression analysis
single nucleotide polymorphism
Adult
Aged
Carbon-Carbon Ligases
Cohort Studies
Dose-Response Relationship, Drug
Egypt
European Continental Ancestry Group
Female
Humans
Linkage Disequilibrium
Male
Microsatellite Repeats
Middle Aged
Peptide Synthases
Polymorphism, Single Nucleotide
Regression Analysis
Syntaxin 1
Warfarin
TitleImpact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in European-Americans and Egyptians
TypeArticle
Pagination36-42
Issue Number1
Volume Number9


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