Browsing Academic by Subject "Metabolomics"
Now showing items 1-7 of 7
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Can atorvastatin with metformin change the natural history of prostate cancer as characterized by molecular, metabolomic, imaging and pathological variables? A randomized controlled trial protocol
( Elsevier , 2016 , Article)Background Atorvastatin and metformin are known energy restricting mimetic agents that act synergistically to produce molecular and metabolic changes in advanced prostate cancer (PCa). This trial seeks to determine whether ... -
Genome-wide association study identifies a novel association between a cardiovascular gene polymorphism and superior athletic performance
( Qatar University Press , 2020 , Poster)Background: Research into the genetic predisposition to superior athletic performance has been a hindered by the underpowered studies and the small effect size of identified genetic variants. The aims of this study were ... -
Identifying metabolic alterations in newly diagnosed small cell lung cancer patients
( Elsevier , 2021 , Article)BackgroundSmall cell lung cancer (SCLC) is a malignant disease with poor prognosis. At the time of diagnosis most patients are already in a metastatic stage. Current diagnosis is based on imaging, histopathology, and ... -
Metabolic profiling of pre-gestational and gestational diabetes mellitus identifies novel predictors of pre-term delivery.
( BMC , 2020 , Article)Pregnant women with gestational diabetes mellitus (GDM) or type 2 diabetes mellitus (T2DM) are at increased risks of pre-term labor, hypertension and preeclampsia. In this study, metabolic profiling of blood samples collected ... -
Metabolic signature of obesity-associated insulin resistance and type 2 diabetes.
( BMC , 2019 , Article)Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. ... -
Metabolomics of lean/overweight insulin resistant females reveals alterations in steroids and fatty acids.
( Endocrine Society , 2020 , Article)The global diabetes epidemic is largely attributed to obesity-triggered metabolic syndrome. However, the impact of insulin resistance (IR) prior to obesity on the high prevalence of diabetes and the molecular mediators ... -
Statistical methods and resources for biomarker discovery using metabolomics.
( BMC , 2023 , Article Review)Metabolomics is a dynamic tool for elucidating biochemical changes in human health and disease. Metabolic profiles provide a close insight into physiological states and are highly volatile to genetic and environmental ...