Distinct neuropsychological correlates in positive and negative formal thought disorder syndromes: The thought and language disorder scale in endogenous psychoses
Date
2016Author
Nagels A.a FahrmannStratmann M.a
Ghazi S.a
Schales C.a
Frauenheim M.a
Turner L.a
Hornig T.b
Katzev M.b
Muller-Isberner R.c
Grosvald M.d
Krug A.a
Kircher T.a
Kircher, Tilo
...show more authors ...show less authors
Metadata
Show full item recordAbstract
The correlation of formal thought disorder (FTD) symptoms and subsyndromes with neuropsychological dimensions is as yet unclear. Evidence for a dysexecutive syndrome and semantic access impairments has been discussed in positive FTD, albeit focusing mostly on patients with schizophrenia. We investigated the correlation of the full range of positive and negative as well as subjective and objective FTD with neuropsychological domains in different patient groups. Patients with ICD-10 schizophrenia (n = 51), depression (n = 51), and bipolar mania (n = 18), as well as healthy subjects (n = 60), were interviewed with the Rating Scale for the Assessment of Objective and Subjective Formal Thought and Language Disorder (TALD) and assessed using a multidimensional neuropsychological test battery (executive function, semantic and lexical verbal fluency, attention, working memory, and abstract thinking). Partial correlation analysis, controlling for age and word knowledge, revealed significant results for the objective positive FTD dimension and executive dysfunctions. Objective negative FTD was associated with deficits in lexico-semantic retrieval, as well as attention and working memory dysfunctions. The results suggest that different neuropsychological substrates correlate with the multidimensional and phenomenologically different FTD syndromes. FTD is a complex, multidimensional syndrome with a variety of neuropsychological impairments, which should be accounted for in future studies investigating the pathogenesis of FTD.
Collections
- English Literature & Linguistics [99 items ]
Related items
Showing items related by title, author, creator and subject.
-
A rating scale for the assessment of objective and subjective formal thought and language disorder (TALD)
Kircher, Tilo; Krug, Axel; Stratmann, Mirjam; Ghazi, Sayed; Schales, Christian; Frauenheim, Michael; Turner, Lena; Fahrmann, Paul; Hornig, Tobias; Katzev, Michael; Grosvald, Michael; Muller-Isberner, Rudiger; Nagels, Arne... more authors ... less authors ( Elsevier , 2014 , Article)Formal thought disorder (FTD) is a core syndrome of schizophrenia. However, patients with other diagnoses, such as mania and depression amongst others, also present with FTD. We introduce a novel, comprehensive clinical ... -
Profile of Mental and Behavioral Disorders Among Preschoolers in a Tertiary Care Hospital in Oman: A Retrospective Study
Al-Sharbati, Marwan M.; Al-Farsi, Yahya M.; Al-Sharbati, Zena M.; Al-Sulaimani, Fatima; Ouhtit, Allal; Al-Adawi, Samir... more authors ... less authors ( Oman Medical Specialty Board , 2016 , Article)Objectives Early diagnosis and prompt treatment of mental and behavioral disorders in preschoolers is critical for a better prognosis, ultimately leading to improved quality of life for both the child and the family. ... -
Effectiveness of pharmacological and psychological interventions for treating post-traumatic stress disorder in adults with childhood abuse: Protocol for a systematic review and network meta-analysis
Alhussaini, Nour Waleed; Riaz, Muhammad ( BMJ Publishing Group , 2021 , Article)Introduction Post-traumatic stress disorder (PTSD) is a debilitating mental disorder that develops after being exposed to a traumatic event. PTSD is common among adults who have experienced physical/sexual childhood abuse. ...