Browsing Medicine Research by Subject "Cardiovascular disease"
Now showing items 1-10 of 10
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Adipose tissue mitochondrial dysfunction and cardiometabolic diseases: On the search for novel molecular targets
( Elsevier , 2022 , Article)Cardiometabolic diseases present an escalating global health and economic burden. Such a surge is driven by epidemic prevalence rates of metabolic disorders, such as obesity and type 2 diabetes, and their associated ... -
Cannabinoids and Myocardial Ischemia: Novel insights, Updated Mechanisms, and Implications for Myocardial Infarction
( Bentham Science Publishers , 2022 , Article)Cannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits and relatively less adverse health effects ... -
Epac as a tractable therapeutic target
( Elsevier , 2023 , Article)In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ... -
Mechanisms underlying the effects of caloric restriction on hypertension
( Elsevier , 2022 , Article)Hypertension is a major risk factor for cardiovascular disease (CVD) as well as a major contributor to all-cause mortality and disability worldwide. The pathophysiology of hypertension is highly attributed to a dysfunctional ... -
Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases
( Elsevier , 2021 , Article)Cardiovascular disease (CVD) is the leading cause of death worldwide. A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. Owing to ... -
MicroRNA-mediated regulation of LDL receptor: biological and pharmacological implications.
( Europe PM , 2023 , Article)One of the main causes of atherosclerosis is a disruption in cellular cholesterol hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining cholesterol homeostasis by the receptor-mediated ... -
Reactive oxygen species: Modulators of phenotypic switch of vascular smooth muscle cells
( MDPI , 2020 , Article Review)Reactive oxygen species (ROS) are natural byproducts of oxygen metabolism in the cell. At physiological levels, they play a vital role in cell signaling. However, high ROS levels cause oxidative stress, which is implicated ... -
Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function
( Elsevier , 2022 , Article Review)Cardiovascular disease (CVD) continues to be the primary cause of global mortality. Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and function, evident by their vital roles in modulating ... -
Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress
( Elsevier , 2021 , Article)Endoplasmic reticulum (ER) stress is an inflammatory response that contributes to endothelial dysfunction, a hallmark of cardiovascular diseases, in close interplay with oxidative stress. Recently, Sestrin2 (SESN2) emerged ... -
The role of protein tyrosine phosphatase (PTP)-1B in cardiovascular disease and its interplay with insulin resistance
( MDPI AG , 2019 , Article Review)Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major ...