Browsing Medicine Research by Subject "Diabetes"
Now showing items 1-10 of 10
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Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1/2-ROCK signaling pathway and attenuates diabetes-induced vascular remodeling and dysfunction.
( Elsevier , 2019 , Article)We investigated whether chronic administration of nano-sized polyamidoamine (PAMAM) dendrimers can have beneficial effects on diabetes-induced vascular dysfunction by inhibiting the epidermal growth factor receptor ... -
Clinical characteristics of 51,815 patients presenting with positive and negative SARS-CoV-2 swab results in primary health care settings: Priority populations for vaccination
( Elsevier , 2021 , Article)We read with interest Brendish et al. study on the comparison between patients with SARS-CoV-2 positive and negative swab results.1 The study compared the clinical characteristics of adult hospitalised patients with ... -
Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)The abnormal accumulation of methylglyoxal (MG) leading to increased glycation of protein and DNA has emerged as an important metabolic stress, dicarbonyl stress, linked to aging, and disease. Increased MG glycation produces ... -
Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential
( Elsevier , 2021 , Article)Drug delivery systems or vectors are usually needed to improve the bioavailability and effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an organ, tissue or cellular level. However, emerging ... -
Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)The recent discovery of the glucose-induced stabilization of hexokinase-2 (HK2) to proteolysis in cell dysfunction in model hyperglycemia has revealed a likely key initiating factor contributing to the development of insulin ... -
Potential causes of male and female infertility in Qatar
( Elsevier , 2020 , Article Review)A steady decline in the fertility rate has been observed in Qatar during the past fifty years. Therefore, infertility is considered a national priority in Qatar, a pronatalist society. This review article summarises the ... -
Protein glycation – biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine
( Elsevier , 2021 , Article)Protein glycation provides a biomarker in widespread clinical use, glycated hemoglobin HbA1c (A1C). It is a biomarker for diagnosis of diabetes and prediabetes and of medium-term glycemic control in patients with established ... -
Screening for diabetes and impaired glucose metabolism in Qatar: Models’ development and validation
( Elsevier , 2021 , Article)AimTo establish two scoring models for identifying individuals at risk of developing Impaired Glucose Metabolism (IGM) or Type two Diabetes Mellitus (T2DM) in Qatari. Materials and methodsA sample of 2000 individuals, from ... -
The role of protein tyrosine phosphatase (PTP)-1B in cardiovascular disease and its interplay with insulin resistance
( MDPI AG , 2019 , Article Review)Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major ... -
Voltage dependence of the Ca2+ transient in endocardial and epicardial myocytes from the left ventricle of Goto Kakizaki type 2 diabetic rats
( Springer New York LLC , 2018 , Article)Diabetes mellitus is a major global health disorder and, currently, over 450 million people have diabetes with 90% suffering from type 2 diabetes. Left untreated, diabetes may lead to cardiovascular diseases which are a ...